Controlling Ser/Thr protein phosphatase PP1 activity and function through interaction with regulatory subunits

Antonio Casamayor; Joaquín Ariño

doi:10.1016/bs.apcsb.2020.06.004

Controlling Ser/Thr protein phosphatase PP1 activity and function through interaction with regulatory subunits

Antonio Casamayor, Joaquín Ariño^*

^*Corresponding author for this work

Institut de Biotecnologia i Biomedicina & Departament de Bioquímica i Biologia Molecular

Research output: Contribution to journal › Review article › Research › peer-review

11 Citations (Scopus)

Abstract

Protein phosphatase 1 is a major Ser/Thr protein phosphatase activity in eukaryotic cells. It is composed of a catalytic polypeptide (PP1C), with little substrate specificity, that interacts with a large variety of proteins of diverse structure (regulatory subunits). The diversity of holoenzymes that can be formed explain the multiplicity of cellular functions under the control of this phosphatase. In quite a few cases, regulatory subunits have an inhibitory role, downregulating the activity of the phosphatase. In this chapter we shall introduce PP1C and review the most relevant families of PP1C regulatory subunits, with particular emphasis in describing the structural basis for their interaction.

Original language	American English
Pages (from-to)	231-288
Number of pages	58
Journal	Advances in Protein Chemistry and Structural Biology
Volume	122
DOIs	https://doi.org/10.1016/bs.apcsb.2020.06.004
Publication status	Published - 1 Jan 2020

Keywords

Enzyme inhibition
Protein phosphatases
Protein-protein interaction
Regulatory subunits
Targeting subunits

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10.1016/bs.apcsb.2020.06.004

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title = "Controlling Ser/Thr protein phosphatase PP1 activity and function through interaction with regulatory subunits",

abstract = "Protein phosphatase 1 is a major Ser/Thr protein phosphatase activity in eukaryotic cells. It is composed of a catalytic polypeptide (PP1C), with little substrate specificity, that interacts with a large variety of proteins of diverse structure (regulatory subunits). The diversity of holoenzymes that can be formed explain the multiplicity of cellular functions under the control of this phosphatase. In quite a few cases, regulatory subunits have an inhibitory role, downregulating the activity of the phosphatase. In this chapter we shall introduce PP1C and review the most relevant families of PP1C regulatory subunits, with particular emphasis in describing the structural basis for their interaction.",

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T1 - Controlling Ser/Thr protein phosphatase PP1 activity and function through interaction with regulatory subunits

AU - Casamayor, Antonio

AU - Ariño, Joaquín

PY - 2020/1/1

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N2 - Protein phosphatase 1 is a major Ser/Thr protein phosphatase activity in eukaryotic cells. It is composed of a catalytic polypeptide (PP1C), with little substrate specificity, that interacts with a large variety of proteins of diverse structure (regulatory subunits). The diversity of holoenzymes that can be formed explain the multiplicity of cellular functions under the control of this phosphatase. In quite a few cases, regulatory subunits have an inhibitory role, downregulating the activity of the phosphatase. In this chapter we shall introduce PP1C and review the most relevant families of PP1C regulatory subunits, with particular emphasis in describing the structural basis for their interaction.

AB - Protein phosphatase 1 is a major Ser/Thr protein phosphatase activity in eukaryotic cells. It is composed of a catalytic polypeptide (PP1C), with little substrate specificity, that interacts with a large variety of proteins of diverse structure (regulatory subunits). The diversity of holoenzymes that can be formed explain the multiplicity of cellular functions under the control of this phosphatase. In quite a few cases, regulatory subunits have an inhibitory role, downregulating the activity of the phosphatase. In this chapter we shall introduce PP1C and review the most relevant families of PP1C regulatory subunits, with particular emphasis in describing the structural basis for their interaction.

KW - Enzyme inhibition

KW - Protein phosphatases

KW - Protein-protein interaction

KW - Regulatory subunits

KW - Targeting subunits

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U2 - 10.1016/bs.apcsb.2020.06.004

DO - 10.1016/bs.apcsb.2020.06.004

M3 - Artículo de revisión

C2 - 32951813

AN - SCOPUS:85088791224

VL - 122

SP - 231

EP - 288

ER -

Controlling Ser/Thr protein phosphatase PP1 activity and function through interaction with regulatory subunits

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Keywords

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