Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: A replication study

M. Ribasés, J. A. Ramos-Quiroga, C. Sánchez-Mora, R. Bosch, V. Richarte, G. Palomar, X. Gastaminza, A. Bielsa, M. Arcos-Burgos, M. Muenke, F. X. Castellanos, B. Cormand, M. Bayés, M. Casas

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Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable developmental disorder characterized by a persistent impairing pattern of inattention and/or hyperactivity-impulsivity. Using families from a genetic isolate, the Paisa population from Colombia, and five independent datasets from four different populations (United States, Germany, Norway and Spain), a highly consistent association was recently reported between ADHD and the latrophilin 3 (LPHN3) gene, a brain-specific member of the LPHN subfamily of G-protein-coupled receptors that is expressed in ADHD-related regions, such as amygdala, caudate nucleus, cerebellum and cerebral cortex. To replicate the association between LPHN3 and ADHD in adults, we undertook a case-control association study in 334 adult patients with ADHD and 334 controls with 43 single nucleotide polymorphisms (SNPs) covering the LPNH3 gene. Single- and multiple-marker analyses showed additional evidence of association between LPHN3 and combined type ADHD in adulthood [P = 0.0019; df = 1; odds ratio (OR) = 1.82 (1.25-2.70) and P = 5.1e-05; df = 1; OR = 2.25 (1.52-3.34), respectively]. These results further support the LPHN3 contribution to combined type ADHD, and specifically to the persistent form of the disorder, and point at this new neuronal pathway as a common susceptibility factor for ADHD throughout the lifespan. © 2010 The Authors. Genes, Brain and Behavior © 2010 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society.
Original languageEnglish
Pages (from-to)149-157
JournalGenes, Brain and Behavior
Volume10
Issue number2
DOIs
Publication statusPublished - 1 Mar 2011

Keywords

  • Adult ADHD
  • Attention-deficit/hyperactivity disorder
  • Case-control association study
  • LPHN3

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    Ribasés, M., Ramos-Quiroga, J. A., Sánchez-Mora, C., Bosch, R., Richarte, V., Palomar, G., Gastaminza, X., Bielsa, A., Arcos-Burgos, M., Muenke, M., Castellanos, F. X., Cormand, B., Bayés, M., & Casas, M. (2011). Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: A replication study. Genes, Brain and Behavior, 10(2), 149-157. https://doi.org/10.1111/j.1601-183X.2010.00649.x