Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response

Neuroscience

• Methadone 100%
• Pharmacokinetics 33%
• Phenotype 16%
• Opioid 16%
• Opioid Dependence 16%
• Cytochrome P450 2D6 16%
• Diagnostic and Statistical Manual of Mental Disorders 8%
• Insulin 8%
• Cytochrome P450 8%
• Cytochrome P450 2C19 8%
• ABC Transporter Subfamily B 8%
• Gene 8%
• Genotype 8%
• Cytochrome P450 2C9 8%
• Cytochrome P450 3A5 8%
• CYP2B6 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Methadone 100%
• Pharmacokinetics 33%
• Opiate 16%
• CYP2D6 16%
• Opiate Addiction 16%
• Diseases 8%
• Insulin 8%
• P-Glycoprotein 8%
• CYP2C19 8%
• Cytochrome P450 8%
• DSM-IV 8%
• CYP2C9 8%
• CYP2B6 8%
• Cytochrome P450 3A5 8%
• Pharmacogenetics 8%
• Urinalysis 8%