Continuous flow analytical microsystems based on low-temperature co-fired ceramic technology. Integrated potentiometric detection based on solvent polymeric ion-selective electrodes

Nuria Ibanez-Garcia, Manel Bautista Mercader, Zaira Mendes Da Rocha, Carlos Antonio Seabra, Mário Ricardo Góngora-Rubio, Julián Alonso Chamarro

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Abstract

In this paper, the low-temperature co-fired ceramics (LTCC) technology, which has been commonly used for electronic applications, is presented as a useful alternative to construct continuous flow analytical microsystems. This technology enables not only the fabrication of complex three-dimensional structures rapidly and at a realistic cost but also the integration of the elements needed to carry out a whole analytical process, such as pretreatment steps, mixers, and detection systems. In this work, a simple and general procedure for the integration of ion-selective electrodes based on liquid ion exchanger is proposed and illustrated by using ammonium- and nitrate-selective membranes. Additionally, a screen-printed reference electrode was easily incorporated into the microfluidic LTCC structure allowing a complete on-chip integration of the potentiometric detection. Analytical features of the proposed systems are presented. © 2006 American Chemical Society.
Original languageEnglish
Pages (from-to)2985-2992
JournalAnalytical Chemistry
Volume78
Issue number9
DOIs
Publication statusPublished - 1 May 2006

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