Contact sensitization to limonene and linalool hydroperoxides in Spain: a GEIDAC* prospective study

Gustavo Deza, Begoña García-Bravo, Juan F. Silvestre, Maria A. Pastor-Nieto, Ricardo González-Pérez, Felipe Heras-Mendaza, Pedro Mercader, Virginia Fernández-Redondo, Bo Niklasson, Ana M. Giménez-Arnau, J. Armario Hita, L. Borrego Hernando, J. Carrascosa Carrillo, S. Córdoba Guijarro, J. García Gavín, M. Gattica Ortega, J. Gómez de la Fuente, M. Hervella Garcés, J. Ortiz de Frutos, M. Rodríguez SernaI. Ruíz González, P. Sánchez Pedreño, J. Sánchez Pérez, E. Serra Baldrich, J. Armario Hita, L. Borrego Hernando, J. Carrascosa Carrillo, S. Córdoba Guijarro, J. García Gavín, M. Gattica Ortega, J. Gómez de la Fuente, M. Hervella Garcés, J. Ortiz de Frutos, M. Rodríguez Serna, I. Ruíz González, P. Sánchez Pedreño, J. Sánchez Pérez, E. Serra Baldrich

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34 Citations (Scopus)

Abstract

© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Background: Limonene and linalool are common fragrance terpenes widely used in cosmetic, household and hygiene products. Their primary oxidation products formed after air exposure, the hydroperoxides, have been recognized as important contact haptens. Objectives: To investigate the prevalence of contact allergy to hydroperoxides of limonene (Lim-OOHs) and hydroperoxides of linalool (Lin-OOHs) in Spain, and to define the optimal concentration for screening in consecutive patients. Methods: Three different concentrations of Lim-OOHs (0.1%, 0.2% and 0.3% pet.) and Lin-OOHs (0.25%, 0.5% and 1.0% pet.) were simultaneously tested in 3639 consecutive patients at 22 departments of dermatology in Spain. Results: Lim-OOHs at 0.1%, 0.2% and 0.3% yielded positive patch test reactions in 1.4%, 3.4% and 5.1% of the tested patients, respectively; and Lin-OOHs at 0.25%, 0.5% and 1.0% yielded positive reactions in 1.3%, 2.9% and 4.9% of the tested patients, respectively. Few irritant (1.5–1.9%) and doubtful reactions (0.4–0.5%) to both terpene hydroperoxides were registered at the highest concentrations tested. Conclusions: Lim-OOHs and Lin-OOHs can be considered as common causes of contact allergy, and their inclusion in an extended baseline patch test series therefore seems to be appropriate. The patch test preparations of Lim-OOHs 0.3% pet. and Lin-OOHs 1.0% pet. are useful tools for screening of contact sensitization.
Original languageEnglish
Pages (from-to)74-80
JournalContact Dermatitis
Volume76
Issue number2
DOIs
Publication statusPublished - 1 Feb 2017

Keywords

  • allergic contact dermatitis
  • fragrance allergy
  • hydroperoxides
  • limonene
  • linalool

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