Consumption of polyunsaturated fat improves the saturated fatty acid-mediated impairment of HDL antioxidant potential

Lídia Cedó, Jari Metso, David Santos, Jose Luís Sánchez-Quesada, Josep Julve, Annabel García-León, Josefina Mora-Brugués, Matti Jauhiainen, Francisco Blanco-Vaca, Joan Carles Escolà-Gil

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13 Citations (Scopus)


© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Scope: The present study aimed to compare the effects of diets containing high-fat, high-cholesterol and saturated fatty acids (HFHC-SFA) and HFHC-polyunsaturated fatty acids-containing (HFHC-PUFA) diets on two major antiatherogenic functions of HDL, the HDL antioxidant function and the macrophage-to-feces reverse cholesterol transport. Methods and results: Experiments were carried out in mice fed a low-fat, low-cholesterol (LFLC) diet, an HFHC-SFA diet or an HFHC-PUFA diet in which SFAs were partly replaced with an alternative high-linoleic and α-linolenic fat source. The HFHC-SFA caused a significant increase in serum HDL cholesterol and phospholipids as well as elevated levels of oxidized HDL and oxidized LDL. Replacing SFA with PUFA significantly reduced the levels of these oxidized lipoproteins and enhanced the ability of HDL to protect LDL from oxidation. The SFA-mediated impairment of HDL antioxidant potential was not associated with the cholesterol content of the diet, obesity or insulin resistance. In contrast, the effect of the HFHC diets on fecal macrophage-derived cholesterol excretion was independent of the fatty acid source. Conclusion: SFA intake impairs the antioxidant potential of HDL and increases serum levels of oxidized lipoprotein species whereas the antioxidant potential of HDL is enhanced after PUFA consumption.
Original languageEnglish
Pages (from-to)1987-1996
JournalMolecular Nutrition and Food Research
Issue number10
Publication statusPublished - 1 Jan 2015


  • HDL
  • Oxidation
  • Polyunsaturated fatty acids
  • Reverse cholesterol transport
  • Saturated fatty acids


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