Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between β-Arrestin Isoforms

Eshan Ghosh, Hemlata Dwivedi, Mithu Baidya, Ashish Srivastava, Punita Kumari, Tomek Stepniewski, Hee Ryung Kim, Mi Hye Lee, Jaana van Gastel, Madhu Chaturvedi, Debarati Roy, Shubhi Pandey, Jagannath Maharana, Ramon Guixà-González, Louis M. Luttrell, Ka Young Chung, Somnath Dutta, Jana Selent, Arun K. Shukla

Research output: Contribution to journalArticleResearch

14 Citations (Scopus)

Abstract

© 2019 The Author(s) Ghosh et al. discover structural differences between β-arrestin isoforms (β-arrestin 1 and 2), which are universal regulators of signaling and trafficking of G-protein-coupled receptors (GPCRs). These findings have direct implications for understanding the regulatory and signaling paradigms of GPCRs and designing novel therapeutics targeting this important class of receptors.
Original languageEnglish
Pages (from-to)3287-3299.e6
JournalCell Reports
Volume28
DOIs
Publication statusPublished - 24 Sep 2019

Keywords

  • antibody fragments
  • biased agonism
  • biosensors
  • cellular signaling
  • desensitization
  • electron microscopy
  • GPCRs
  • negative staining
  • β-arrestins

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