Concentration of putrescine in plasma, frontal cortex and hippocampus of rats after systemic administration of the convulsants N-methyl-D-aspartate, pentylentetrazol, picrotoxinine, lindane and 4-aminopyridine

L. Giménez-Llort; E. Martínez; L. Camón; N. De Vera

doi:10.1016/S0304-3940(96)13073-1

Concentration of putrescine in plasma, frontal cortex and hippocampus of rats after systemic administration of the convulsants N-methyl-D-aspartate, pentylentetrazol, picrotoxinine, lindane and 4-aminopyridine

L. Giménez-Llort, E. Martínez, L. Camón, N. De Vera^*

^*Corresponding author for this work

Department of Psychiatry and Legal Medicine

Institute for Biomedical Research of Barcelona (IIBB-CSIC)

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

The motor responses (such as stereotypic behavior or convulsions) induced in rats by N-methyl-D-aspartate (NMDA) administered systemically were followed by a rapid, moderate increase in the putrescine concentration in plasma which preceded an increase in this mine in the brain. This effect was not observed following the convulsions evoked by pentylentetrazol, picrotoxinine, lindane or 4-aminopyridine. However, all the convulsants assayed induced a mild increase in the concentration of putrescine in the frontal cortex and hippocampus. A differential activation of the ornithine decarboxylase (ODC)/polyamine system in both cerebral and peripheral tissues could account for these results.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Neurosci. lett.
Volume	217
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(96)13073-1
Publication status	Published - 1996

Keywords

4-Aminopyridine
Blood plasma
Brain
Convulsion
Lindane
N-methyl-D-aspartate
Pentylenetetrazol
Picrotoxinine
Polyamines

Access to Document

10.1016/S0304-3940(96)13073-1

Fingerprint

Dive into the research topics of 'Concentration of putrescine in plasma, frontal cortex and hippocampus of rats after systemic administration of the convulsants N-methyl-D-aspartate, pentylentetrazol, picrotoxinine, lindane and 4-aminopyridine'. Together they form a unique fingerprint.

Cite this

@article{03bbfe13581848bfbe905ee7fa8085ec,

title = "Concentration of putrescine in plasma, frontal cortex and hippocampus of rats after systemic administration of the convulsants N-methyl-D-aspartate, pentylentetrazol, picrotoxinine, lindane and 4-aminopyridine",

abstract = "The motor responses (such as stereotypic behavior or convulsions) induced in rats by N-methyl-D-aspartate (NMDA) administered systemically were followed by a rapid, moderate increase in the putrescine concentration in plasma which preceded an increase in this mine in the brain. This effect was not observed following the convulsions evoked by pentylentetrazol, picrotoxinine, lindane or 4-aminopyridine. However, all the convulsants assayed induced a mild increase in the concentration of putrescine in the frontal cortex and hippocampus. A differential activation of the ornithine decarboxylase (ODC)/polyamine system in both cerebral and peripheral tissues could account for these results.",

keywords = "4-Aminopyridine, Blood plasma, Brain, Convulsion, Lindane, N-methyl-D-aspartate, Pentylenetetrazol, Picrotoxinine, Polyamines",

author = "L. Gim{\'e}nez-Llort and E. Mart{\'i}nez and L. Cam{\'o}n and {De Vera}, N.",

note = "Funding Information: This study was supported by grants SAF 92-0913 and FIS 93/0350. The skillful technical assistance of L. Campa is acknowledged. Departments of Neurochemistry and Pharmacology and Toxicology are recipient of GRQ-1995 grants from Generalitat de Catalunya.",

year = "1996",

doi = "10.1016/S0304-3940(96)13073-1",

language = "English",

volume = "217",

pages = "1--4",

journal = "Neurosci. lett.",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

Concentration of putrescine in plasma, frontal cortex and hippocampus of rats after systemic administration of the convulsants N-methyl-D-aspartate, pentylentetrazol, picrotoxinine, lindane and 4-aminopyridine. / Giménez-Llort, L.; Martínez, E.; Camón, L. et al.
In: Neurosci. lett., Vol. 217, No. 1, 1996, p. 1-4.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Concentration of putrescine in plasma, frontal cortex and hippocampus of rats after systemic administration of the convulsants N-methyl-D-aspartate, pentylentetrazol, picrotoxinine, lindane and 4-aminopyridine

AU - Giménez-Llort, L.

AU - Martínez, E.

AU - Camón, L.

AU - De Vera, N.

N1 - Funding Information: This study was supported by grants SAF 92-0913 and FIS 93/0350. The skillful technical assistance of L. Campa is acknowledged. Departments of Neurochemistry and Pharmacology and Toxicology are recipient of GRQ-1995 grants from Generalitat de Catalunya.

PY - 1996

Y1 - 1996

N2 - The motor responses (such as stereotypic behavior or convulsions) induced in rats by N-methyl-D-aspartate (NMDA) administered systemically were followed by a rapid, moderate increase in the putrescine concentration in plasma which preceded an increase in this mine in the brain. This effect was not observed following the convulsions evoked by pentylentetrazol, picrotoxinine, lindane or 4-aminopyridine. However, all the convulsants assayed induced a mild increase in the concentration of putrescine in the frontal cortex and hippocampus. A differential activation of the ornithine decarboxylase (ODC)/polyamine system in both cerebral and peripheral tissues could account for these results.

AB - The motor responses (such as stereotypic behavior or convulsions) induced in rats by N-methyl-D-aspartate (NMDA) administered systemically were followed by a rapid, moderate increase in the putrescine concentration in plasma which preceded an increase in this mine in the brain. This effect was not observed following the convulsions evoked by pentylentetrazol, picrotoxinine, lindane or 4-aminopyridine. However, all the convulsants assayed induced a mild increase in the concentration of putrescine in the frontal cortex and hippocampus. A differential activation of the ornithine decarboxylase (ODC)/polyamine system in both cerebral and peripheral tissues could account for these results.

KW - 4-Aminopyridine

KW - Blood plasma

KW - Brain

KW - Convulsion

KW - Lindane

KW - N-methyl-D-aspartate

KW - Pentylenetetrazol

KW - Picrotoxinine

KW - Polyamines

UR - http://www.scopus.com/inward/record.url?scp=0029805465&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(96)13073-1

DO - 10.1016/S0304-3940(96)13073-1

M3 - Article

C2 - 8905725

SN - 0304-3940

VL - 217

SP - 1

EP - 4

JO - Neurosci. lett.

JF - Neurosci. lett.

IS - 1

ER -

Concentration of putrescine in plasma, frontal cortex and hippocampus of rats after systemic administration of the convulsants N-methyl-D-aspartate, pentylentetrazol, picrotoxinine, lindane and 4-aminopyridine

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this