Thinking it through: Details of the transition-state structures of the chorismate to prephenate rearrangement in the active site of the 1F7 (N33S) mutant were obtained by computer-aided rational design. This method may be used to determine whether antibody scaffolds are evolutionary dead ends or if they can be further improved. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH &. Co. KGaA.
- Catalytic antibody
- Chorismate-prephenate rearrangement
- Computer chemistry
- Quantum mechanics/molecular mechanics