Abstract
Thinking it through: Details of the transition-state structures of the chorismate to prephenate rearrangement in the active site of the 1F7 (N33S) mutant were obtained by computer-aided rational design. This method may be used to determine whether antibody scaffolds are evolutionary dead ends or if they can be further improved. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH &. Co. KGaA.
Original language | English |
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Pages (from-to) | 286-290 |
Journal | Angewandte Chemie - International Edition |
Volume | 46 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 16 Jan 2007 |
Keywords
- Catalytic antibody
- Chorismate-prephenate rearrangement
- Computer chemistry
- Enzymes
- Quantum mechanics/molecular mechanics