Computational analysis of candidate prion-like proteins in bacteria and their role

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

© 2015 Iglesias, de Groot and Ventura. Prion proteins were initially associated with diseases such as Creutzfeldt Jakob and transmissible spongiform encephalopathies. However, deeper research revealed them as versatile tools, exploited by the cells to execute fascinating functions, acting as epigenetic elements or building membrane free compartments in eukaryotes. One of the most intriguing properties of prion proteins is their ability to propagate a conformational assembly, even across species. In this context, it has been observed that bacterial amyloids can trigger the formation of protein aggregates by interacting with host proteins. As our life is closely linked to bacteria, either through a parasitic or symbiotic relationship, prion-like proteins produced by bacterial cells might play a role in this association. Bioinformatics is helping us to understand the factors that determine conformational conversion and infectivity in prion-like proteins. We have used PrionScan to detect prion domains in 839 different bacteria proteomes, detecting 2200 putative prions in these organisms. We studied this set of proteins in order to try to understand their functional role and structural properties. Our results suggest that these bacterial polypeptides are associated to peripheral rearrangement, macromolecular assembly, cell adaptability, and invasion. Overall, these data could reveal new threats and therapeutic targets associated to infectious diseases.
Original languageEnglish
Article number1123
JournalFrontiers in Microbiology
Volume6
Issue numberOCT
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • Amyloid
  • Bacteria
  • Pathogenesis
  • Prion
  • Protein aggregation

Fingerprint Dive into the research topics of 'Computational analysis of candidate prion-like proteins in bacteria and their role'. Together they form a unique fingerprint.

  • Cite this