Compromised immunologic recovery in treatment-experienced patients with HIV infection receiving both tenofovir disoproxil fumarate and didanosine in the TORO studies

Eugènia Negredo; Anna Bonjoch; Roger Paredes; Jordi Puig; Bonaventura Clotet

doi:https://doi.org/10.1086/432879

Compromised immunologic recovery in treatment-experienced patients with HIV infection receiving both tenofovir disoproxil fumarate and didanosine in the TORO studies

Eugènia Negredo, Anna Bonjoch, Roger Paredes, Jordi Puig, Bonaventura Clotet

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

22 Citations (Scopus)

Abstract

The effect of therapy with a combination of tenofovir and full-dose didanosine on increases in CD4+ cell count was examined in 2 large trials of treatment-experienced patients with human immunodeficiency virus (HIV) infection (the T-20 versus Optimized Regimen Only [TORO] 1 and 2 clinical trials). Individuals receiving both agents showed little additional increase in CD4+ cell count after week 8 of therapy, whereas those receiving 1 or neither of the agents had continuous increases over a 48-week period. © 2005 by the Infectious Diseases Society of America. All rights reserved.

Original language	English
Pages (from-to)	901-905
Journal	Clinical Infectious Diseases
Volume	41
DOIs	https://doi.org/10.1086/432879
Publication status	Published - 15 Sep 2005

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title = "Compromised immunologic recovery in treatment-experienced patients with HIV infection receiving both tenofovir disoproxil fumarate and didanosine in the TORO studies",

abstract = "The effect of therapy with a combination of tenofovir and full-dose didanosine on increases in CD4+ cell count was examined in 2 large trials of treatment-experienced patients with human immunodeficiency virus (HIV) infection (the T-20 versus Optimized Regimen Only [TORO] 1 and 2 clinical trials). Individuals receiving both agents showed little additional increase in CD4+ cell count after week 8 of therapy, whereas those receiving 1 or neither of the agents had continuous increases over a 48-week period. {\textcopyright} 2005 by the Infectious Diseases Society of America. All rights reserved.",

author = "Eug{\`e}nia Negredo and Anna Bonjoch and Roger Paredes and Jordi Puig and Bonaventura Clotet",

year = "2005",

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doi = "https://doi.org/10.1086/432879",

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Compromised immunologic recovery in treatment-experienced patients with HIV infection receiving both tenofovir disoproxil fumarate and didanosine in the TORO studies. / Negredo, Eugènia; Bonjoch, Anna; Paredes, Roger; Puig, Jordi; Clotet, Bonaventura.

In: Clinical Infectious Diseases, Vol. 41, 15.09.2005, p. 901-905.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Puig, Jordi

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AB - The effect of therapy with a combination of tenofovir and full-dose didanosine on increases in CD4+ cell count was examined in 2 large trials of treatment-experienced patients with human immunodeficiency virus (HIV) infection (the T-20 versus Optimized Regimen Only [TORO] 1 and 2 clinical trials). Individuals receiving both agents showed little additional increase in CD4+ cell count after week 8 of therapy, whereas those receiving 1 or neither of the agents had continuous increases over a 48-week period. © 2005 by the Infectious Diseases Society of America. All rights reserved.

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DO - https://doi.org/10.1086/432879

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