Comprehensive embryo analysis of advanced maternal age-related aneuploidies and mosaicism by short comparative genomic hybridization

Mariona Rius, Gemma Daina, Albert Obradors, Laia Ramos, Esther Velilla, Sílvia Fernández, Olga Martínez-Passarell, Jordi Benet, Joaquima Navarro

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33 Citations (Scopus)

Abstract

The short comparative genomic hybridization (short-CGH) method was used to perform a comprehensive cytogenetic study of isolated blastomeres from advanced maternal age embryos, discarded after fluorescent in situ hybridization (FISH) preimplantation genetic screening (PGS), detecting aneuploidies (38.5% of which corresponded to chromosomes not screened by 9-chromosome FISH), structural aberrations (31.8%), and mosaicism (77.3%). The short-CGH method was subsequently applied in one PGS, achieving a twin pregnancy. © 2011 American Society for Reproductive Medicine, Published by Elsevier Inc.
Original languageEnglish
Pages (from-to)413-416
JournalFertility and Sterility
Volume95
Issue number1
DOIs
Publication statusPublished - 1 Jan 2011

Keywords

  • CGH
  • chromosome abnormality
  • FISH
  • mosaicism
  • PGS

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