The short comparative genomic hybridization (short-CGH) method was used to perform a comprehensive cytogenetic study of isolated blastomeres from advanced maternal age embryos, discarded after fluorescent in situ hybridization (FISH) preimplantation genetic screening (PGS), detecting aneuploidies (38.5% of which corresponded to chromosomes not screened by 9-chromosome FISH), structural aberrations (31.8%), and mosaicism (77.3%). The short-CGH method was subsequently applied in one PGS, achieving a twin pregnancy. © 2011 American Society for Reproductive Medicine, Published by Elsevier Inc.
- chromosome abnormality
Rius, M., Daina, G., Obradors, A., Ramos, L., Velilla, E., Fernández, S., Martínez-Passarell, O., Benet, J., & Navarro, J. (2011). Comprehensive embryo analysis of advanced maternal age-related aneuploidies and mosaicism by short comparative genomic hybridization. Fertility and Sterility, 95(1), 413-416. https://doi.org/10.1016/j.fertnstert.2010.07.1051