Complete resolution of symptoms of primary orthostatic tremor with perampanel

María Ruiz-Julián, Jorge Luís Orozco, Alexandre Gironell

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)


© 2018 Ruiz-Julián et al. Background: Primary orthostatic tremor (POT) is an infrequent disorder whose physiopathology is unknown. Current medication is largely ineffective or only offers mild benefits. Case Report: A 75-year-old female with refractory POT treated with 4 mg/day of perampanel achieved complete symptom resolution. Owing to adverse effects, the patient reduced intake to 2 mg/day, but even at this lower dose the benefit was maintained. Discussion: We report the complete resolution of POT symptoms using low doses of perampanel, an antiepileptic drug that blocks glutamate-mediated postsynaptic excitation. Further controlled studies are necessary to confirm this finding.
Original languageEnglish
JournalTremor and Other Hyperkinetic Movements
Publication statusPublished - 1 Jan 2018


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