Competing mortality in oropharyngeal carcinoma according to human papillomavirus status

Joan Lop, Jacinto García, Montserrat López, Miren Taberna, Marisa Mena, Laia Alemany, Miquel Quer, Xavier León

Research output: Contribution to journalArticleResearch

5 Citations (Scopus)

Abstract

© 2018 Wiley Periodicals, Inc. Background: The objective of the present study is to assess differences in the competing causes of death in patients with oropharyngeal carcinoma (OPC) as a function of the human papillomavirus (HPV) status. Methods: We studied retrospectively 423 patients with OPC with known HPV status. Among the patients included in the study, 53 (12.5%) were HPV-positive. We analyzed overall survival and competing causes of mortality according to the HPV status of the patients. Results: Patients with HPV-negative tumors had lower OPC cancer-specific survival (P =.0001), second primary neoplasm survival (P =.0001), and noncancer-related causes survival (P =.13) than patients with HPV-positive tumors. This resulted in significant differences in overall survival depending on HPV status (P =.0001). Conclusion: Conclusion: HPV-positive OPC has a better overall survival than HPV-negative OPC. Patients with HPV-positive tumors presented a significant lower OPC cancer-specific and second primary neoplasm mortality and a marginally nonsignificant lower noncancer mortality as compared to HPV-negative tumors.
Original languageEnglish
Pages (from-to)1328-1334
JournalHead and Neck
Volume41
DOIs
Publication statusPublished - 1 May 2019

Keywords

  • competing mortality
  • head and neck cancer
  • HPV
  • noncancer-related deaths
  • oropharyngeal carcinoma
  • second primary cancer

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