Competing mortality in oropharyngeal carcinoma according to human papillomavirus status

Joan Lop; Jacinto García; Montserrat López; Miren Taberna; Marisa Mena; Laia Alemany; Miquel Quer; Xavier León

doi:10.1002/hed.25559

Competing mortality in oropharyngeal carcinoma according to human papillomavirus status

Joan Lop, Jacinto García, Montserrat López, Miren Taberna, Marisa Mena, Laia Alemany, Miquel Quer, Xavier León

Department of Surgery

Research output: Contribution to journal › Article › Research

8 Citations (Scopus)

Abstract

© 2018 Wiley Periodicals, Inc. Background: The objective of the present study is to assess differences in the competing causes of death in patients with oropharyngeal carcinoma (OPC) as a function of the human papillomavirus (HPV) status. Methods: We studied retrospectively 423 patients with OPC with known HPV status. Among the patients included in the study, 53 (12.5%) were HPV-positive. We analyzed overall survival and competing causes of mortality according to the HPV status of the patients. Results: Patients with HPV-negative tumors had lower OPC cancer-specific survival (P =.0001), second primary neoplasm survival (P =.0001), and noncancer-related causes survival (P =.13) than patients with HPV-positive tumors. This resulted in significant differences in overall survival depending on HPV status (P =.0001). Conclusion: Conclusion: HPV-positive OPC has a better overall survival than HPV-negative OPC. Patients with HPV-positive tumors presented a significant lower OPC cancer-specific and second primary neoplasm mortality and a marginally nonsignificant lower noncancer mortality as compared to HPV-negative tumors.

Original language	English
Pages (from-to)	1328-1334
Journal	Head and Neck
Volume	41
DOIs	https://doi.org/10.1002/hed.25559
Publication status	Published - 1 May 2019

Keywords

competing mortality
head and neck cancer
HPV
noncancer-related deaths
oropharyngeal carcinoma
second primary cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{74eff27ee8964ac3abe2d6c53c606570,

title = "Competing mortality in oropharyngeal carcinoma according to human papillomavirus status",

abstract = "{\textcopyright} 2018 Wiley Periodicals, Inc. Background: The objective of the present study is to assess differences in the competing causes of death in patients with oropharyngeal carcinoma (OPC) as a function of the human papillomavirus (HPV) status. Methods: We studied retrospectively 423 patients with OPC with known HPV status. Among the patients included in the study, 53 (12.5%) were HPV-positive. We analyzed overall survival and competing causes of mortality according to the HPV status of the patients. Results: Patients with HPV-negative tumors had lower OPC cancer-specific survival (P =.0001), second primary neoplasm survival (P =.0001), and noncancer-related causes survival (P =.13) than patients with HPV-positive tumors. This resulted in significant differences in overall survival depending on HPV status (P =.0001). Conclusion: Conclusion: HPV-positive OPC has a better overall survival than HPV-negative OPC. Patients with HPV-positive tumors presented a significant lower OPC cancer-specific and second primary neoplasm mortality and a marginally nonsignificant lower noncancer mortality as compared to HPV-negative tumors.",

keywords = "competing mortality, head and neck cancer, HPV, noncancer-related deaths, oropharyngeal carcinoma, second primary cancer",

author = "Joan Lop and Jacinto Garc{\'i}a and Montserrat L{\'o}pez and Miren Taberna and Marisa Mena and Laia Alemany and Miquel Quer and Xavier Le{\'o}n",

year = "2019",

month = may,

day = "1",

doi = "10.1002/hed.25559",

language = "English",

volume = "41",

pages = "1328--1334",

journal = "Head and Neck",

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TY - JOUR

T1 - Competing mortality in oropharyngeal carcinoma according to human papillomavirus status

AU - Lop, Joan

AU - García, Jacinto

AU - López, Montserrat

AU - Taberna, Miren

AU - Mena, Marisa

AU - Alemany, Laia

AU - Quer, Miquel

AU - León, Xavier

PY - 2019/5/1

Y1 - 2019/5/1

N2 - © 2018 Wiley Periodicals, Inc. Background: The objective of the present study is to assess differences in the competing causes of death in patients with oropharyngeal carcinoma (OPC) as a function of the human papillomavirus (HPV) status. Methods: We studied retrospectively 423 patients with OPC with known HPV status. Among the patients included in the study, 53 (12.5%) were HPV-positive. We analyzed overall survival and competing causes of mortality according to the HPV status of the patients. Results: Patients with HPV-negative tumors had lower OPC cancer-specific survival (P =.0001), second primary neoplasm survival (P =.0001), and noncancer-related causes survival (P =.13) than patients with HPV-positive tumors. This resulted in significant differences in overall survival depending on HPV status (P =.0001). Conclusion: Conclusion: HPV-positive OPC has a better overall survival than HPV-negative OPC. Patients with HPV-positive tumors presented a significant lower OPC cancer-specific and second primary neoplasm mortality and a marginally nonsignificant lower noncancer mortality as compared to HPV-negative tumors.

AB - © 2018 Wiley Periodicals, Inc. Background: The objective of the present study is to assess differences in the competing causes of death in patients with oropharyngeal carcinoma (OPC) as a function of the human papillomavirus (HPV) status. Methods: We studied retrospectively 423 patients with OPC with known HPV status. Among the patients included in the study, 53 (12.5%) were HPV-positive. We analyzed overall survival and competing causes of mortality according to the HPV status of the patients. Results: Patients with HPV-negative tumors had lower OPC cancer-specific survival (P =.0001), second primary neoplasm survival (P =.0001), and noncancer-related causes survival (P =.13) than patients with HPV-positive tumors. This resulted in significant differences in overall survival depending on HPV status (P =.0001). Conclusion: Conclusion: HPV-positive OPC has a better overall survival than HPV-negative OPC. Patients with HPV-positive tumors presented a significant lower OPC cancer-specific and second primary neoplasm mortality and a marginally nonsignificant lower noncancer mortality as compared to HPV-negative tumors.

KW - competing mortality

KW - head and neck cancer

KW - HPV

KW - noncancer-related deaths

KW - oropharyngeal carcinoma

KW - second primary cancer

U2 - 10.1002/hed.25559

DO - 10.1002/hed.25559

M3 - Article

C2 - 30549389

SN - 1043-3074

VL - 41

SP - 1328

EP - 1334

JO - Head and Neck

JF - Head and Neck

ER -

Competing mortality in oropharyngeal carcinoma according to human papillomavirus status

Abstract

Keywords

UN SDGs

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