Comparison of two commercially available gamma interferon blood tests for immunodiagnosis of tuberculosis

Jose Domínguez, Juan Ruiz-Manzano, Malú De Souza-Galvão, Irene Latorre, Celia Milà, Silvia Blanco, M. Ángeles Jiménez, Cristina Prat, Alicia Lacoma, Neus Altet, Vicente Ausina

Research output: Contribution to journalArticleResearchpeer-review

112 Citations (Scopus)

Abstract

We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT.TB was negative in 50% of cases. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Original languageEnglish
Pages (from-to)168-171
JournalClinical and Vaccine Immunology
Volume15
Issue number1
DOIs
Publication statusPublished - 1 Jan 2008

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