Comparison of two commercially available gamma interferon blood tests for immunodiagnosis of tuberculosis

Jose Domínguez; Juan Ruiz-Manzano; Malú De Souza-Galvão; Irene Latorre; Celia Milà; Silvia Blanco; M. Ángeles Jiménez; Cristina Prat; Alicia Lacoma; Neus Altet; Vicente Ausina

doi:10.1128/CVI.00364-07

Comparison of two commercially available gamma interferon blood tests for immunodiagnosis of tuberculosis

Jose Domínguez, Juan Ruiz-Manzano, Malú De Souza-Galvão, Irene Latorre, Celia Milà, Silvia Blanco, M. Ángeles Jiménez, Cristina Prat, Alicia Lacoma, Neus Altet, Vicente Ausina

Department of Genetics and Microbiology

Research output: Contribution to journal › Article › Research › peer-review

120 Citations (Scopus)

Abstract

We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT.TB was negative in 50% of cases. Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Original language	English
Pages (from-to)	168-171
Journal	Clinical and Vaccine Immunology
Volume	15
Issue number	1
DOIs	https://doi.org/10.1128/CVI.00364-07
Publication status	Published - 1 Jan 2008

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abstract = "We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT.TB was negative in 50% of cases. Copyright {\textcopyright} 2008, American Society for Microbiology. All Rights Reserved.",

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AU - Domínguez, Jose

AU - Ruiz-Manzano, Juan

AU - De Souza-Galvão, Malú

AU - Latorre, Irene

AU - Milà, Celia

AU - Blanco, Silvia

AU - Jiménez, M. Ángeles

AU - Prat, Cristina

AU - Lacoma, Alicia

AU - Altet, Neus

AU - Ausina, Vicente

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AB - We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT.TB was negative in 50% of cases. Copyright © 2008, American Society for Microbiology. All Rights Reserved.

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DO - 10.1128/CVI.00364-07

M3 - Article

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JO - Clinical and Vaccine Immunology

JF - Clinical and Vaccine Immunology

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Comparison of two commercially available gamma interferon blood tests for immunodiagnosis of tuberculosis

Abstract

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