Comparison of regenerative and reinnervating capabilities of different functional types of nerve fibers

Xavier Navarro, Enrique VerdÚ, Miquel ButÍ

    Research output: Contribution to journalArticleResearchpeer-review

    102 Citations (Scopus)

    Abstract

    Functional reinnervation of sweat glands (SGs), skin, and muscle in the mouse paw after sciatic nerve lesions was evaluated to allow comparisons of the regeneration efficiency of different functional types of nerve fibers. In four groups of mice the sciatic nerve was crushed, sectioned, and left unrepaired or repaired by suture or tubulization. Reappearance of SG secretion and pinprick responses occurred slightly earlier than recordings of compound muscle and nerve action potentials in all groups. The degree of reinnervation, with respect to preoperative control values, of SGs and skin nociceptors was higher than the amplitude of the action potentials, mainly when the nerve injury was severe. The chances for recovery progressively decreased with the severity of the lesion, affecting the larger nerve fibers most. These results indicate that, after injuries of peripheral nerves, all types of nerve fibers are able to regenerate in the mouse, although small size fibers (sudomotor and nociceptive) allow for a higher degree of functional recovery than large myelinated fibers (skeletomotor and sensory). © 1994 Academic Press. All rights reserved.
    Original languageEnglish
    Pages (from-to)217-224
    JournalExperimental Neurology
    Volume129
    DOIs
    Publication statusPublished - 1 Jan 1994

    Fingerprint

    Dive into the research topics of 'Comparison of regenerative and reinnervating capabilities of different functional types of nerve fibers'. Together they form a unique fingerprint.

    Cite this