TY - JOUR
T1 - Comparison of quality of life after stereotactic body radiotherapy and surgery for early-stage prostate cancer
AU - Katz, Alan
AU - Ferrer, Montserrat
AU - Suárez, José F.
AU - Alonso, Jordi
AU - Becerra, Adela Virginia
AU - Cunillera, Oriol
AU - Garín, Olatz
AU - Pardo, Yolanda
AU - Pont, Angels
AU - Boladeras, Ana
AU - Ferrer, Ferran
AU - Guedea, Ferran
AU - Martínez, Evelyn
AU - Padin, Victoria Eugenia
AU - Pera, Joan
AU - Ventura, Montse
AU - Aguiló, Ferran
AU - Pastor, Sergio
AU - Prats, Josep Maria
AU - de León, Javier Ponce
AU - Villavicencio, Humberto
AU - Batista, Jose Emilio
AU - Craven-Bratle, Jordi
AU - Sancho, Gemma
AU - Ayala, Adriana
AU - de Paula, Belen
AU - Fernández, Pablo
AU - Guix, Benjamin
AU - Herruzo, Ismael
AU - Hernández, Helena
AU - Muñoz, Víctor
AU - Hervas, Asunción
AU - Ramos, Alfredo
AU - Macias, Víctor
AU - Solé, Josep
AU - Bonet, Marta
AU - Marcos, Pilar
AU - Mariño, Alfonso
AU - Ortiz, María José
AU - Prada, Pedro J.
PY - 2012/11/20
Y1 - 2012/11/20
N2 - Background: As the long-term efficacy of stereotactic body radiation therapy (SBRT) becomes established and other prostate cancer treatment approaches are refined and improved, examination of quality of life (QOL) following prostate cancer treatment is critical in driving both patient and clinical treatment decisions. We present the first study to compare QOL after SBRT and radical prostatectomy, with QOL assessed at approximately the same times pre- and post-treatment and using the same validated QOL instrument.Methods: Patients with clinically localized prostate cancer were treated with either radical prostatectomy (n = 123 Spanish patients) or SBRT (n = 216 American patients). QOL was assessed using the Expanded Prostate Cancer Index Composite (EPIC) grouped into urinary, sexual, and bowel domains. For comparison purposes, SBRT EPIC data at baseline, 3 weeks, 5, 11, 24, and 36 months were compared to surgery data at baseline, 1, 6, 12, 24, and 36 months. Differences in patient characteristics between the two groups were assessed using Chi-squared tests for categorical variables and t-tests for continuous variables. Generalized estimating equation (GEE) models were constructed for each EPIC scale to account for correlation among repeated measures and used to assess the effect of treatment on QOL.Results: The largest differences in QOL occurred in the first 1-6 months after treatment, with larger declines following surgery in urinary and sexual QOL as compared to SBRT, and a larger decline in bowel QOL following SBRT as compared to surgery. Long-term urinary and sexual QOL declines remained clinically significantly lower for surgery patients but not for SBRT patients.Conclusions: Overall, these results may have implications for patient and physician clinical decision making which are often influenced by QOL. These differences in sexual, urinary and bowel QOL should be closely considered in selecting the right treatment, especially in evaluating the value of non-invasive treatments, such as SBRT. © 2012 Katz et al.; licensee BioMed Central Ltd.
AB - Background: As the long-term efficacy of stereotactic body radiation therapy (SBRT) becomes established and other prostate cancer treatment approaches are refined and improved, examination of quality of life (QOL) following prostate cancer treatment is critical in driving both patient and clinical treatment decisions. We present the first study to compare QOL after SBRT and radical prostatectomy, with QOL assessed at approximately the same times pre- and post-treatment and using the same validated QOL instrument.Methods: Patients with clinically localized prostate cancer were treated with either radical prostatectomy (n = 123 Spanish patients) or SBRT (n = 216 American patients). QOL was assessed using the Expanded Prostate Cancer Index Composite (EPIC) grouped into urinary, sexual, and bowel domains. For comparison purposes, SBRT EPIC data at baseline, 3 weeks, 5, 11, 24, and 36 months were compared to surgery data at baseline, 1, 6, 12, 24, and 36 months. Differences in patient characteristics between the two groups were assessed using Chi-squared tests for categorical variables and t-tests for continuous variables. Generalized estimating equation (GEE) models were constructed for each EPIC scale to account for correlation among repeated measures and used to assess the effect of treatment on QOL.Results: The largest differences in QOL occurred in the first 1-6 months after treatment, with larger declines following surgery in urinary and sexual QOL as compared to SBRT, and a larger decline in bowel QOL following SBRT as compared to surgery. Long-term urinary and sexual QOL declines remained clinically significantly lower for surgery patients but not for SBRT patients.Conclusions: Overall, these results may have implications for patient and physician clinical decision making which are often influenced by QOL. These differences in sexual, urinary and bowel QOL should be closely considered in selecting the right treatment, especially in evaluating the value of non-invasive treatments, such as SBRT. © 2012 Katz et al.; licensee BioMed Central Ltd.
KW - Prostate cancer
KW - Prostatectomy
KW - Quality of life
KW - Stereotactic body radiotherapy
U2 - https://doi.org/10.1186/1748-717X-7-194
DO - https://doi.org/10.1186/1748-717X-7-194
M3 - Article
SN - 1748-717X
VL - 7
JO - Radiation Oncology
JF - Radiation Oncology
M1 - 194
ER -
