Comparison of effectiveness and discontinuation of interferon-free therapy for hepatitis C in prison inmates and noninmates

A. Marco, M. Roget, M. Cervantes, M. Forné, R. Planella, M. Miquel, J. Ortiz, M. Navarro, C. Gallego, M. Vergara, Guido Almada, Meritxell Casas, Antonio da Silva, Blai Dalmau, Rafael A. Guerrero, Joaquím Profitós, Ana Ruíz, Montserrat Sala, Carmen Sarriera, Ana SastreConcepció Solé, Núria Teixidó, Carlos Touzón

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Abstract

© 2018 John Wiley & Sons Ltd Chronic hepatitis C treatment with direct acting antiviral (DAA) therapy during incarceration is an attractive option, due to its short duration and to the possibility of directly observed treatment or supervision. The aim of this study is to compare the effectiveness and rates of discontinuation of DAA treatment in prisoners and nonprisoners. We studied all patients treated in the 10 prisons of Catalonia and at 3 public hospitals in the Barcelona area between 1 January 2015 and 30 April 2016. We analysed sustained viral response (SVR) and rates of discontinuation through intention-to-treat and modified-intention-to-treat analyses, the latter excluding discontinuations due to release from prison. One hundred and eighty-eight inmates and 862 noninmates were included. Prisoners were significantly younger than nonprisoners, with higher proportions of men, drug users, HIV infection, genotypes 1a and 3 and more treatment with psychiatric drugs. Overall, 98.4% of patients completed treatment. The discontinuation rate was low, but higher in inmates (3.7% vs 1.2% noninmates; P =.003) and in community patients >65 years old (2.8% vs 1.2% in under 65 seconds; P =.008). Among the inmates, 7 (42.8%) discontinuations were due to release. SVR was 93.1% in inmates vs 96.5% in noninmates (P =.08) by intention-to-treat and 95.1% vs 96.5% (P =.37) by modified intention-to-treat. Virologic failure rates were similar (3.8% vs 3% in noninmates; P =.60). SVR, virologic failure and discontinuation rates were similar in inmates and noninmates. Currently, prisons are considered a priority for the implementation of DAA. Improved coordination between penitentiary and community health systems would help to ensure therapeutic continuity in released prisoners.
Original languageEnglish
Pages (from-to)1280-1286
JournalJournal of Viral Hepatitis
Volume25
DOIs
Publication statusPublished - 1 Nov 2018

Keywords

  • antiviral agents
  • chronic hepatitis C
  • comparative effectiveness research
  • prisons
  • treatment outcome

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    Marco, A., Roget, M., Cervantes, M., Forné, M., Planella, R., Miquel, M., Ortiz, J., Navarro, M., Gallego, C., Vergara, M., Almada, G., Casas, M., da Silva, A., Dalmau, B., Guerrero, R. A., Profitós, J., Ruíz, A., Sala, M., Sarriera, C., ... Touzón, C. (2018). Comparison of effectiveness and discontinuation of interferon-free therapy for hepatitis C in prison inmates and noninmates. Journal of Viral Hepatitis, 25, 1280-1286. https://doi.org/10.1111/jvh.12940