Comparison of commensal and clinical isolates for diversity of plasmids in Escherichia coli and Klebsiella pneumoniae

Judith Rodríguez-Navarro; Elisenda Miró; Maryury Brown-Jaque; Juan Carlos Hurtado; Albert Moreno; Maite Muniesa; Juan José González-López; Jordi Vila; Paula Espinal; Ferran Navarro

doi:10.1128/AAC.02064-19

Comparison of commensal and clinical isolates for diversity of plasmids in Escherichia coli and Klebsiella pneumoniae

Judith Rodríguez-Navarro, Elisenda Miró, Maryury Brown-Jaque, Juan Carlos Hurtado, Albert Moreno, Maite Muniesa, Juan José González-López, Jordi Vila, Paula Espinal^*, Ferran Navarro

^*Corresponding author for this work

Department of Genetics and Microbiology

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

In this study, the plasmid content of clinical and commensal strains was analyzed and compared. The replicon profile was similar in both populations, except for L, M, A/C, and N (detected only in clinical strains) and HI1 (only in commensal strains). Although I1 and F were the most frequent replicons, only IncI1, sequence type 12 (ST12) was associated with bla_CMY-2 in both populations. In contrast, the widespread resistant IncF plasmids were not linked to a single epidemic plasmid.

Original language	English
Article number	e02064-19
Journal	Antimicrobial Agents and Chemotherapy
Volume	64
Issue number	5
DOIs	https://doi.org/10.1128/AAC.02064-19
Publication status	Published - May 2020

Keywords

Antimicrobial resistance
Enterobacteriaceae
Plasmid epidemiology
PMLST
Replicon

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.02064-19

https://ddd.uab.cat/record/285185

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Rodríguez-Navarro, J., Miró, E., Brown-Jaque, M., Hurtado, J. C., Moreno, A., Muniesa, M., González-López, J. J., Vila, J., Espinal, P., & Navarro, F. (2020). Comparison of commensal and clinical isolates for diversity of plasmids in Escherichia coli and Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy, 64(5), Article e02064-19. https://doi.org/10.1128/AAC.02064-19

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abstract = "In this study, the plasmid content of clinical and commensal strains was analyzed and compared. The replicon profile was similar in both populations, except for L, M, A/C, and N (detected only in clinical strains) and HI1 (only in commensal strains). Although I1 and F were the most frequent replicons, only IncI1, sequence type 12 (ST12) was associated with blaCMY-2 in both populations. In contrast, the widespread resistant IncF plasmids were not linked to a single epidemic plasmid.",

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T1 - Comparison of commensal and clinical isolates for diversity of plasmids in Escherichia coli and Klebsiella pneumoniae

AU - Rodríguez-Navarro, Judith

AU - Miró, Elisenda

AU - Brown-Jaque, Maryury

AU - Hurtado, Juan Carlos

AU - Moreno, Albert

AU - Muniesa, Maite

AU - González-López, Juan José

AU - Vila, Jordi

AU - Espinal, Paula

AU - Navarro, Ferran

PY - 2020/5

Y1 - 2020/5

N2 - In this study, the plasmid content of clinical and commensal strains was analyzed and compared. The replicon profile was similar in both populations, except for L, M, A/C, and N (detected only in clinical strains) and HI1 (only in commensal strains). Although I1 and F were the most frequent replicons, only IncI1, sequence type 12 (ST12) was associated with blaCMY-2 in both populations. In contrast, the widespread resistant IncF plasmids were not linked to a single epidemic plasmid.

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KW - Antimicrobial resistance

KW - Enterobacteriaceae

KW - Plasmid epidemiology

KW - PMLST

KW - Replicon

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SN - 0066-4804

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JO - Antimicrobial Agents and Chemotherapy

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ER -

Comparison of commensal and clinical isolates for diversity of plasmids in Escherichia coli and Klebsiella pneumoniae

Abstract

Keywords

UN SDGs

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