Comparing transplant glomerulopathy in the absence of C4d deposition and donor-specific antibodies to chronic antibody-mediated rejection

Irina B. Torres, Maite Salcedo, Francesc Moreso, Joana Sellarés, Eva Castellá, M. Antonieta Azancot, Manel Perelló, Carme Cantarell, Daniel Serón

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16 Citations (Scopus)

Abstract

© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Introduction: Transplant glomerulopathy (TG) is the characteristic lesion of chronic antibody-mediated rejection (AMR). However, in some patients presents with no circulating HLA antibodies or C4d positivity. Aim: Patients with TG accomplishing criteria for chronic AMR were compared to patients with isolated TG. Patients and Methods: We reviewed late (>6 months) graft biopsies performed between 2007 and 2010 (n = 75). Biopsies with C4d-negative TG and no circulating donor-specific antibody were called isolated TG (n = 12), and chronic AMR was defined according to Banff consensus (n = 17). HLA antibodies were evaluated by Luminex technology. Immunohistochemistry was performed to quantify graft infiltrating cells. Results: Patients with isolated TG were older (52 ± 14 vs. 35 ± 14; p = 0.0048), received grafts from older donors (54 ± 16 vs. 41 ± 18; p = 0.0554), and displayed a lower inflammation in the glomerular (g-score: 0.5 ± 0.5 vs. 1.0 ± 0.9; p = 0.0865; CD3 positive cells/glomeruli: 1.5 ± 2.9 vs. 4.4 ± 4.1; p = 0.0147), interstitial (i-score: 1.2 ± 0.9 vs. 1.9 ± 1.0; p = 0.0685; CD45 positive cells/hpf: 18 ± 11 vs. 57 ± 68; p = 0.0132), and peritubular capillary (ptc-score 0.2 ± 0.6 vs. 1.1 ± 0.9; p = 0.0089; CD45 positive cells/hpf: 3.7 ± 3.1 vs. 10.1 ± 7.4; p = 0.0290) compartments. Fifteen grafts were lost and graft survival was significantly lower in patients with chronic AMR (p = 0.0122). Conclusion: Isolated TG is associated with less severe allograft inflammation and with a better outcome than chronic AMR.
Original languageEnglish
Pages (from-to)1148-1154
JournalClinical Transplantation
Volume28
Issue number10
DOIs
Publication statusPublished - 1 Oct 2014

Keywords

  • chronic antibody-mediated rejection
  • donor-specific antibodies
  • transplant glomerulopathy

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