Comparative study on the usefulness of antibacterial prophylaxis with levofloxacin in patients submitted to hematopoietic stem cell transplantation

Jesús Fernandez Sojo, Montserrat Batlle Massana, Mireia Morgades, Susana Vives Polo, María Dolores Quesada, Josep María Ribera Santasusana

Research output: Contribution to journalArticleResearchpeer-review

Abstract

© 2015 Elsevier España, S.L.U. Background Bacterial infection remains a frequent complication in patients receiving a hematopoietic stem cell transplantation (HSCT). However, the impact of the antibacterial prophylaxis mortality in these patients is controversial. Patients and methods Retrospective comparison of 2 consecutive groups of patients undergoing HSCT receiving (n = 132) or not (n = 107) antibacterial prophylaxis with levofloxacin. Results 41% of patients receiving prophylaxis with levofloxacin had microbiologically documented infection (MDI) with bacteremia, compared with 40% of those not receiving levofloxacin. The frequency of gram-negative bacteremia was 11 and 38%, the resistance to levofloxacin was 39 and 14%, and the mortality was 8 and 7%, respectively. Conclusions In our experience, the use of levofloxacin as prophylaxis in HSCT was associated with a lower frequency of gram-negative bacteremia but was not associated with a decreased rate of MDI and did not influence their outcome. In contrast, there was an increase in quinolone resistance in patients treated with levofloxacin.
Original languageEnglish
Pages (from-to)16-19
JournalMedicina Clinica
Volume146
Issue number1
DOIs
Publication statusPublished - 1 Jan 2016

Keywords

  • Bacteremia
  • Hematopoietic stem cell transplant
  • Levofloxacin
  • Prophylaxis
  • Resistance

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