Comparative study on the antithrombotic efficacy of hirudin, heparin and a low-molecular weight heparin in preventing experimentally induced venous thrombosis

Manuel Monreal, F. Galego, L. Monreal, A. M. Angles, J. Monasterio, B. Oller

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

In a random, blind study, we compared the antithrombotic potential of unfractioned heparin, a low-molecular weight heparin (LMWH) and a recombinant hirudin (r-hirudin) given subcutaneously in a jugular vein thrombosis model in rabbits. All drugs and placebo were injected subcutaneously 2 h before inducing experimental thrombosis. A good thrombo- prophylactic effect was obtained with either LMWH and r- hirudin as compared with placebo. By contrast, no significant differences were found between groups in bleeding time. We also found a small (non-significant) prolongation of the activated partial thromboplastin time in the r-hirudin-treated animals. As for thrombin time, r-hirudin-treated rabbits exhibited too much sensitivity, with noncoagulable end-points. In our study, r-hirudin at the dose used seemed to be as effective as LMWH is in the prophylaxis of venous thrombosis. © 1993 S. Karger AG, Basel.
Original languageEnglish
Pages (from-to)179-183
JournalPathophysiology of Haemostasis and Thrombosis
Volume23
Issue number3
DOIs
Publication statusPublished - 1 Jan 1993

Keywords

  • Experimental
  • Heparin
  • Hirudin
  • Low-molecular-weight
  • Prophylaxis
  • Venous thrombosis

Fingerprint Dive into the research topics of 'Comparative study on the antithrombotic efficacy of hirudin, heparin and a low-molecular weight heparin in preventing experimentally induced venous thrombosis'. Together they form a unique fingerprint.

  • Cite this