Comparative study of historical series of differentiated thyroid carcinoma in two tertiary hospitals in Spain versus north American series

Jordi L. Reverter, Eulàlia Colomé, Irene Halperin, Teresa Julián, Gonzalo Díaz, Mireia Mora, Anna Sanmartí, Manuel Puig-Domingo

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9 Citations (Scopus)


Background and objective: There is little national literature on descriptive series of patients with differentiated thyroid carcinoma (DTC) and long-term monitoring in Spain. The aim of our study was to describe the DTC series in two tertiary hospitals [Hospital Clínic de Barcelona (HC) and Hospital Germans Trias i Pujol (HGTiP)] and compare these series with those described in the National Cancer Data Base (NCDB) and the Mayo Clinic, the leading international series by number of patients and length of follow-up. Material and methods: We performed a retrospective review of the medical records of patients diagnosed with DTC in two tertiary hospitals in the Barcelona area. The results were compared with those published by the NCDB and the Mayo Clinic. Results: We reviewed 480 medical records of patients with DTC diagnosed between 1973 and 2006, with a mean follow-up of 16±8 years. No significant differences were observed in clinical characteristics, risk factors or the most frequent form of presentation between the joint HC/HGTiP group and the NCDB series. The most commonly used diagnostic methods were ultrasound and cytology in all series and the main type of surgery was total or nearly total thyroidectomy, with no differences between groups. Postoperative I-131 was administered more often in the HC/HGTiP series (83.9%) than in the NCDB series (55.1%) and in the Mayo Clinic (46%). In the HC/HGTiP group tumor recurrence was 9.3% and mortality 1.8%. Conclusions: The HC and HGTiP series were comparable and the various diagnostic and therapeutic techniques used were similar. This study highlights historical trends in the use of imaging techniques, as well as differences with large American series in some procedures (such as laryngoscopy) and the use of radioiodine therapy. © 2010 SEEN.
Original languageEnglish
Pages (from-to)364-369
JournalEndocrinologia y Nutricion
Issue number8
Publication statusPublished - 1 Oct 2010


  • Comparative study
  • Historical series
  • Thyroid cancer


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