Comparative pharmacokinetics of netobimin metabolites in pregnant ewes

C. Cristòfol; C. Franquelo; M. Navarro; A. Carretero; J. Ruberte; M. Arboix

doi:10.1016/S0034-5288(97)90131-4

Comparative pharmacokinetics of netobimin metabolites in pregnant ewes

C. Cristòfol, C. Franquelo, M. Navarro, A. Carretero, J. Ruberte, M. Arboix

Department of Pharmacology, Therapeutics and Toxicology

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

The pharmacokinetics of netobimin (NTB) metabolites has been investigated in ewes. Non-pregnant ewes and ewes in the first and last third of pregnancy were dosed orally with 20 mg kg bodyweight of NTB. Blood samples were collected from the jugular vein from 30 minutes to 72 hours after administration and plasma samples were analysed by high performance liquid chromatography. Neither NTB nor albendazole (ABZ) were detected in any of the samples analysed. No statistically significant differences were found between the pharmacokinetic parameters of albendazole suphoxide (ABZSO) and albendazole sulphone (ABZSO2) among the three groups of ewes. The peak plasma concentrations (C(max)) ABZSO and ABZSO2 were reached about 10 and 20 hours respectively after administration in all three groups. The ratios of ABZSO/ABZSO2 for C(max) and the areas under the curve (AUC(0-α)) were 6 and 3, respectively, in each group and suggest a low rate of oxidation of sulfoxide to sulphone.

Original language	English
Pages (from-to)	117-120
Journal	Research in Veterinary Science
Volume	62
DOIs	https://doi.org/10.1016/S0034-5288(97)90131-4
Publication status	Published - 1 Jan 1997

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title = "Comparative pharmacokinetics of netobimin metabolites in pregnant ewes",

abstract = "The pharmacokinetics of netobimin (NTB) metabolites has been investigated in ewes. Non-pregnant ewes and ewes in the first and last third of pregnancy were dosed orally with 20 mg kg bodyweight of NTB. Blood samples were collected from the jugular vein from 30 minutes to 72 hours after administration and plasma samples were analysed by high performance liquid chromatography. Neither NTB nor albendazole (ABZ) were detected in any of the samples analysed. No statistically significant differences were found between the pharmacokinetic parameters of albendazole suphoxide (ABZSO) and albendazole sulphone (ABZSO2) among the three groups of ewes. The peak plasma concentrations (C(max)) ABZSO and ABZSO2 were reached about 10 and 20 hours respectively after administration in all three groups. The ratios of ABZSO/ABZSO2 for C(max) and the areas under the curve (AUC(0-α)) were 6 and 3, respectively, in each group and suggest a low rate of oxidation of sulfoxide to sulphone.",

author = "C. Crist{\`o}fol and C. Franquelo and M. Navarro and A. Carretero and J. Ruberte and M. Arboix",

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doi = "10.1016/S0034-5288(97)90131-4",

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T1 - Comparative pharmacokinetics of netobimin metabolites in pregnant ewes

AU - Cristòfol, C.

AU - Franquelo, C.

AU - Navarro, M.

AU - Carretero, A.

AU - Ruberte, J.

AU - Arboix, M.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - The pharmacokinetics of netobimin (NTB) metabolites has been investigated in ewes. Non-pregnant ewes and ewes in the first and last third of pregnancy were dosed orally with 20 mg kg bodyweight of NTB. Blood samples were collected from the jugular vein from 30 minutes to 72 hours after administration and plasma samples were analysed by high performance liquid chromatography. Neither NTB nor albendazole (ABZ) were detected in any of the samples analysed. No statistically significant differences were found between the pharmacokinetic parameters of albendazole suphoxide (ABZSO) and albendazole sulphone (ABZSO2) among the three groups of ewes. The peak plasma concentrations (C(max)) ABZSO and ABZSO2 were reached about 10 and 20 hours respectively after administration in all three groups. The ratios of ABZSO/ABZSO2 for C(max) and the areas under the curve (AUC(0-α)) were 6 and 3, respectively, in each group and suggest a low rate of oxidation of sulfoxide to sulphone.

AB - The pharmacokinetics of netobimin (NTB) metabolites has been investigated in ewes. Non-pregnant ewes and ewes in the first and last third of pregnancy were dosed orally with 20 mg kg bodyweight of NTB. Blood samples were collected from the jugular vein from 30 minutes to 72 hours after administration and plasma samples were analysed by high performance liquid chromatography. Neither NTB nor albendazole (ABZ) were detected in any of the samples analysed. No statistically significant differences were found between the pharmacokinetic parameters of albendazole suphoxide (ABZSO) and albendazole sulphone (ABZSO2) among the three groups of ewes. The peak plasma concentrations (C(max)) ABZSO and ABZSO2 were reached about 10 and 20 hours respectively after administration in all three groups. The ratios of ABZSO/ABZSO2 for C(max) and the areas under the curve (AUC(0-α)) were 6 and 3, respectively, in each group and suggest a low rate of oxidation of sulfoxide to sulphone.

U2 - 10.1016/S0034-5288(97)90131-4

DO - 10.1016/S0034-5288(97)90131-4

M3 - Article

SN - 0034-5288

VL - 62

SP - 117

EP - 120

JO - Research in Veterinary Science

JF - Research in Veterinary Science

ER -

Comparative pharmacokinetics of netobimin metabolites in pregnant ewes

Abstract

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