Combined pleomorphic xanthoastrocytoma-ganglioglioma with BRAF V600E mutation: Case report

Marta Cicuendez; Elena Martinez-Saez; Francisco Martinez-Ricarte; Esteban Cordero Asanza; Juan Sahuquillo

doi:10.3171/2016.1.PEDS15558

Combined pleomorphic xanthoastrocytoma-ganglioglioma with BRAF V600E mutation: Case report

Marta Cicuendez, Elena Martinez-Saez, Francisco Martinez-Ricarte, Esteban Cordero Asanza, Juan Sahuquillo

Department of Morphological Sciences

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

© 2016 AANS. Combined pleomorphic xanthoastrocytoma (PXA) and ganglioglioma (GG) is an extremely rare tumor, with fewer than 20 cases reported. The authors report a case of combined PXA-GG in an 18-year-old man with a history of seizures. The tumor showed necrosis and the BRAF V600E mutation on histological examination, with no evidence of tumor recurrence 1 year after gross-total resection. The BRAF V600E mutation was present, which suggests that both cell lineages may share a common cellular origin.

Original language	English
Pages (from-to)	53-57
Journal	Journal of Neurosurgery: Pediatrics
Volume	18
Issue number	1
DOIs	https://doi.org/10.3171/2016.1.PEDS15558
Publication status	Published - 1 Jul 2016

Keywords

BRAF mutation
Combined pleomorphic xanthoastrocytoma-ganglioglioma
Ganglioglioma
Oncology
Pleomorphic xanthoastrocytoma

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10.3171/2016.1.PEDS15558

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title = "Combined pleomorphic xanthoastrocytoma-ganglioglioma with BRAF V600E mutation: Case report",

abstract = "{\textcopyright} 2016 AANS. Combined pleomorphic xanthoastrocytoma (PXA) and ganglioglioma (GG) is an extremely rare tumor, with fewer than 20 cases reported. The authors report a case of combined PXA-GG in an 18-year-old man with a history of seizures. The tumor showed necrosis and the BRAF V600E mutation on histological examination, with no evidence of tumor recurrence 1 year after gross-total resection. The BRAF V600E mutation was present, which suggests that both cell lineages may share a common cellular origin.",

keywords = "BRAF mutation, Combined pleomorphic xanthoastrocytoma-ganglioglioma, Ganglioglioma, Oncology, Pleomorphic xanthoastrocytoma",

author = "Marta Cicuendez and Elena Martinez-Saez and Francisco Martinez-Ricarte and Asanza, {Esteban Cordero} and Juan Sahuquillo",

year = "2016",

month = jul,

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doi = "10.3171/2016.1.PEDS15558",

language = "English",

volume = "18",

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journal = "Journal of Neurosurgery: Pediatrics",

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T1 - Combined pleomorphic xanthoastrocytoma-ganglioglioma with BRAF V600E mutation: Case report

AU - Cicuendez, Marta

AU - Martinez-Saez, Elena

AU - Martinez-Ricarte, Francisco

AU - Asanza, Esteban Cordero

AU - Sahuquillo, Juan

PY - 2016/7/1

Y1 - 2016/7/1

N2 - © 2016 AANS. Combined pleomorphic xanthoastrocytoma (PXA) and ganglioglioma (GG) is an extremely rare tumor, with fewer than 20 cases reported. The authors report a case of combined PXA-GG in an 18-year-old man with a history of seizures. The tumor showed necrosis and the BRAF V600E mutation on histological examination, with no evidence of tumor recurrence 1 year after gross-total resection. The BRAF V600E mutation was present, which suggests that both cell lineages may share a common cellular origin.

AB - © 2016 AANS. Combined pleomorphic xanthoastrocytoma (PXA) and ganglioglioma (GG) is an extremely rare tumor, with fewer than 20 cases reported. The authors report a case of combined PXA-GG in an 18-year-old man with a history of seizures. The tumor showed necrosis and the BRAF V600E mutation on histological examination, with no evidence of tumor recurrence 1 year after gross-total resection. The BRAF V600E mutation was present, which suggests that both cell lineages may share a common cellular origin.

KW - BRAF mutation

KW - Combined pleomorphic xanthoastrocytoma-ganglioglioma

KW - Ganglioglioma

KW - Oncology

KW - Pleomorphic xanthoastrocytoma

U2 - 10.3171/2016.1.PEDS15558

DO - 10.3171/2016.1.PEDS15558

M3 - Article

VL - 18

SP - 53

EP - 57

JO - Journal of Neurosurgery: Pediatrics

JF - Journal of Neurosurgery: Pediatrics

SN - 1933-0707

IS - 1

ER -

Combined pleomorphic xanthoastrocytoma-ganglioglioma with BRAF V600E mutation: Case report

Abstract

Keywords

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