Combined pleomorphic xanthoastrocytoma-ganglioglioma with BRAF V600E mutation: Case report

Marta Cicuendez, Elena Martinez-Saez, Francisco Martinez-Ricarte, Esteban Cordero Asanza, Juan Sahuquillo

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9 Citations (Scopus)


© 2016 AANS. Combined pleomorphic xanthoastrocytoma (PXA) and ganglioglioma (GG) is an extremely rare tumor, with fewer than 20 cases reported. The authors report a case of combined PXA-GG in an 18-year-old man with a history of seizures. The tumor showed necrosis and the BRAF V600E mutation on histological examination, with no evidence of tumor recurrence 1 year after gross-total resection. The BRAF V600E mutation was present, which suggests that both cell lineages may share a common cellular origin.
Original languageEnglish
Pages (from-to)53-57
JournalJournal of Neurosurgery: Pediatrics
Issue number1
Publication statusPublished - 1 Jul 2016


  • BRAF mutation
  • Combined pleomorphic xanthoastrocytoma-ganglioglioma
  • Ganglioglioma
  • Oncology
  • Pleomorphic xanthoastrocytoma


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