Combined dementia-risk biomarkers in Parkinson's disease: A prospective longitudinal study

Yaroslau Compta, Joana B. Pereira, Jose Ríos, Naroa Ibarretxe-Bilbao, Carme Junqué, Núria Bargalló, Ana Cámara, Mariateresa Buongiorno, Manel Fernández, Claustre Pont-Sunyer, Maria J. Martí*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

98 Citations (Scopus)

Abstract

Neuropsychological (mostly posterior-cortical) deficits, quantitative magnetic resonance imaging (MRI) atrophy patterns, and low cerebrospinal fluid (CSF) levels of amyloid-β have been separately related to worsening cognition in Parkinson's disease (PD). However, these biomarkers have not been longitudinally assessed in combination as PD-dementia predictors. In this prospective longitudinal study, 27 non-demented PD patients underwent CSF, neuropsychological and 3-Tbrain-MRI studies at baseline and were re-assessed 18 months later in terms of progression to dementia (primary outcome) and longitudinal neuropsychological and cortical thickness changes (secondary outcomes). At follow-up 11 patients (41%) had progressed to dementia. Lower CSF amyloid-β, worse verbal learning, semantic fluency and visuoperceptual scores, and thinner superior-frontal/anterior cingulate and precentral regions were significant baseline dementia predictors in binary logistic regressions as quantitative and/or dichotomised traits. All participants without baseline biomarker abnormalities remained non-demented whereas all with abnormalities in each biomarker type progressed to dementia, with intermediate risk for those showing abnormalities in a single to two biomarker types (p=0.006). Both the dementia-outcome and low baseline CSF amyloid-β were prospectively associated with limbic and posterior-cortical neuropsychological decline and frontal, limbic and posterior-cortical thinning from baseline to follow-up. These findings suggest that the combination of CSF amyloid-β, neuropsychological and cortical thickness biomarkers might provide a basis for dementia-risk stratification and progression monitoring in PD.

Original languageAmerican English
Pages (from-to)717-724
Number of pages8
JournalParkinsonism and Related Disorders
Volume19
Issue number8
DOIs
Publication statusPublished - Aug 2013

Keywords

  • Amyloid-β
  • Cerebrospinal fluid
  • Cortical thickness
  • Dementia predictors
  • Longitudinal analysis
  • Parkinson's disease

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