Colonization capacity and serum bactericidal activity of Haemophilus parasuis thy mutants

Anna Bigas, M. Elena Garrido, Ignacio Badiola, Jordi Barbé, Montserrat Llagostera

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10 Citations (Scopus)

Abstract

The bacterial thyA gene encodes the enzyme thymidylate synthase, which is essential for dTMP synthesis and, consequently, for DNA replication. In this work, a Haemophilus parasuis thyA mutant was constructed in order to analyze its colonization characteristics and its capacity to generate serum bactericidal activity in infected guinea pigs. The data showed that colonization by the H. parasuis thyA mutant was much less than that of the wild-type strain. Nevertheless, the mutant generated a strong immunogenic response in the host, as detected by measuring serum bactericidal activity.
Original languageEnglish
Pages (from-to)297-301
JournalInternational Microbiology
Volume9
Issue number4
Publication statusPublished - 1 Jan 2006

Keywords

  • Bactericidal activity
  • Colonization capacity
  • Haemophilus parasuis
  • Immunogenic response
  • thy mutants
  • Vaccine strains

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