COL1A1 haplotypes and hip fracture

Roser Urreizti, Natàlia Garcia-Giralt, José A. Riancho, Jesús González-Macías, Sergi Civit, Roberto Güerri, Guy Yoskovitz, Patricia Sarrion, Leonardo Mellivobsky, Adolfo Díez-Pérez, Xavier Nogués, Susana Balcells, Daniel Grinberg

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13 Citations (Scopus)

Abstract

Fragility fractures resulting from low-trauma events such as a fall from standing height are associated with osteoporosis and are very common in older people, especially women. Three single nucleotide polymorphisms (SNPs) at the COL1A1 gene (rs1107946, rs11327935, and rs1800012) have been widely studied and previously associated with bone mineral density (BMD) and fracture. A rare haplotype (T-delT-T) of these three SNPs was found to be greatly overrepresented in fractured individuals compared with nonfractured controls, thus becoming a good candidate for predicting increased fracture risk. The aim of our study was to assess the association of this haplotype with fracture risk in Spanish individuals. We recruited two independent groups of ∼100 patients with hip fracture (a total of 203 individuals) and compared the genotype and haplotype distributions of the three SNPs in the fractured patients with those of 397 control individuals from the BARCOS Spanish cohort. We found no association with risk of fracture at the genotype level for any of the SNPs, and no differences in the SNP frequencies between the two groups. At the haplotype level, we found no association between the T-delT-T haplotype and fracture. However, we observed a small but significant (p=0.03) association with another rare haplotype, G-insT-T, which was slightly overrepresented in the patient group. Copyright © 2012 American Society for Bone and Mineral Research.
Original languageEnglish
Pages (from-to)950-953
JournalJournal of Bone and Mineral Research
Volume27
DOIs
Publication statusPublished - 1 Apr 2012

Keywords

  • Osteoporosis
  • association
  • collagen
  • epidemiology
  • gene/genetic research
  • matrix proteins
  • polymorphisms
  • population studies
  • snps

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