© 2016 Elsevier España, S.L.U. Cognitive impairments are common in the context of major depressive disorder. Nowadays, there is growing evidence confirming that these alterations are present not only during acute or active depressive episodes, but that they persist for some time after significant remission of depressive symptoms in a substantial percentage of patients who have suffered from this disorder. This study reviews the literature that has addressed this issue with a view to defining the profile and pattern of cognitive dysfunction in remitted depression and establishing its clinical and functional impact. Various studies have assessed impaired cognitive functioning after remission and have demonstrated alterations in distinct cognitive domains; the most important of these alterations involve dysfunctions in attention, memory and executive function. The presence of these alterations significantly affects the patient's functional performance and quality of life and increases the risk of further depressive relapses. There is a need for increased efforts to adequately assess the presence of these alterations in patients who have had depressive symptoms and to develop appropriate therapeutic strategies for their effective management.
|Publication status||Published - 1 Sep 2016|
- Cognitive deficits
- Executive functions
- Major depressive disorder