Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain

E. Quintana; C. Coll; J. Salavedra-Pont; M. Muñoz-San Martín; R. Robles-Cedeño; J. Tomàs-Roig; M. Buxó; C. Matute-Blanch; L. M. Villar; X. Montalban; M. Comabella; H. Perkal; J. Gich; L. Ramió-Torrentà

doi:10.1111/ene.13687

Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain

E. Quintana, C. Coll, J. Salavedra-Pont, M. Muñoz-San Martín, R. Robles-Cedeño, J. Tomàs-Roig, M. Buxó, C. Matute-Blanch, L. M. Villar, X. Montalban, M. Comabella, H. Perkal, J. Gich, L. Ramió-Torrentà

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

20 Citations (Scopus)

Abstract

© 2018 EAN Background and purpose: Chitinase 3-like 1 (CHI3L1) and neurofilament light chain (NF-L) are promising biomarkers of disability in multiple sclerosis (MS). However, their role in cognitive dysfunction remains elusive. Here, we aimed to correlate cerebrospinal fluid (CSF) levels of CHI3L1 and NF-L with cognitive status in MS. Methods: Fifty one recently diagnosed patients were cognitively evaluated and CSF was collected. Levels of CHI3L1 and NF-L were determined by ELISA. Spearman's partial correlation coefficient was performed. Results: After adjusting cognitive scores by age, anxiety and EDSS, association was detected between CHI3L1 levels and Trail Making Test A (r s = 0.348; p = 0.016) and between NF-L levels and Word List Generation (r s = −0.324; p = 0.025). Conclusion: High levels of CSF CHI3L1 and NF-L are associated with cognitive impairment in the early phases of MS.

Original language	English
Pages (from-to)	1189-1191
Journal	European Journal of Neurology
Volume	25
Issue number	9
DOIs	https://doi.org/10.1111/ene.13687
Publication status	Published - 1 Sep 2018

Keywords

biomarkers
chitinase 3-like 1
mild cognitive impairment
multiple sclerosis
neurofilament light chain

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Quintana, E., Coll, C., Salavedra-Pont, J., Muñoz-San Martín, M., Robles-Cedeño, R., Tomàs-Roig, J., Buxó, M., Matute-Blanch, C., Villar, L. M., Montalban, X., Comabella, M., Perkal, H., Gich, J., & Ramió-Torrentà, L. (2018). Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain. European Journal of Neurology, 25(9), 1189-1191. https://doi.org/10.1111/ene.13687

Quintana, E. ; Coll, C. ; Salavedra-Pont, J. ; Muñoz-San Martín, M. ; Robles-Cedeño, R. ; Tomàs-Roig, J. ; Buxó, M. ; Matute-Blanch, C. ; Villar, L. M. ; Montalban, X. ; Comabella, M. ; Perkal, H. ; Gich, J. ; Ramió-Torrentà, L. / Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain. In: European Journal of Neurology. 2018 ; Vol. 25, No. 9. pp. 1189-1191.

@article{3d5a5f7667cc4f148a5c9177eb5c14a2,

title = "Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain",

abstract = "{\textcopyright} 2018 EAN Background and purpose: Chitinase 3-like 1 (CHI3L1) and neurofilament light chain (NF-L) are promising biomarkers of disability in multiple sclerosis (MS). However, their role in cognitive dysfunction remains elusive. Here, we aimed to correlate cerebrospinal fluid (CSF) levels of CHI3L1 and NF-L with cognitive status in MS. Methods: Fifty one recently diagnosed patients were cognitively evaluated and CSF was collected. Levels of CHI3L1 and NF-L were determined by ELISA. Spearman's partial correlation coefficient was performed. Results: After adjusting cognitive scores by age, anxiety and EDSS, association was detected between CHI3L1 levels and Trail Making Test A (r s = 0.348; p = 0.016) and between NF-L levels and Word List Generation (r s = −0.324; p = 0.025). Conclusion: High levels of CSF CHI3L1 and NF-L are associated with cognitive impairment in the early phases of MS.",

keywords = "biomarkers, chitinase 3-like 1, mild cognitive impairment, multiple sclerosis, neurofilament light chain",

author = "E. Quintana and C. Coll and J. Salavedra-Pont and {Mu{\~n}oz-San Mart{\'i}n}, M. and R. Robles-Cede{\~n}o and J. Tom{\`a}s-Roig and M. Bux{\'o} and C. Matute-Blanch and Villar, {L. M.} and X. Montalban and M. Comabella and H. Perkal and J. Gich and L. Rami{\'o}-Torrent{\`a}",

year = "2018",

month = sep,

day = "1",

doi = "10.1111/ene.13687",

language = "English",

volume = "25",

pages = "1189--1191",

journal = "European Journal of Neurology",

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Quintana, E, Coll, C, Salavedra-Pont, J, Muñoz-San Martín, M, Robles-Cedeño, R, Tomàs-Roig, J, Buxó, M, Matute-Blanch, C, Villar, LM, Montalban, X, Comabella, M, Perkal, H, Gich, J & Ramió-Torrentà, L 2018, 'Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain', European Journal of Neurology, vol. 25, no. 9, pp. 1189-1191. https://doi.org/10.1111/ene.13687

Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain. / Quintana, E.; Coll, C.; Salavedra-Pont, J.; Muñoz-San Martín, M.; Robles-Cedeño, R.; Tomàs-Roig, J.; Buxó, M.; Matute-Blanch, C.; Villar, L. M.; Montalban, X.; Comabella, M.; Perkal, H.; Gich, J.; Ramió-Torrentà, L.

In: European Journal of Neurology, Vol. 25, No. 9, 01.09.2018, p. 1189-1191.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain

AU - Quintana, E.

AU - Coll, C.

AU - Salavedra-Pont, J.

AU - Muñoz-San Martín, M.

AU - Robles-Cedeño, R.

AU - Tomàs-Roig, J.

AU - Buxó, M.

AU - Matute-Blanch, C.

AU - Villar, L. M.

AU - Montalban, X.

AU - Comabella, M.

AU - Perkal, H.

AU - Gich, J.

AU - Ramió-Torrentà, L.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - © 2018 EAN Background and purpose: Chitinase 3-like 1 (CHI3L1) and neurofilament light chain (NF-L) are promising biomarkers of disability in multiple sclerosis (MS). However, their role in cognitive dysfunction remains elusive. Here, we aimed to correlate cerebrospinal fluid (CSF) levels of CHI3L1 and NF-L with cognitive status in MS. Methods: Fifty one recently diagnosed patients were cognitively evaluated and CSF was collected. Levels of CHI3L1 and NF-L were determined by ELISA. Spearman's partial correlation coefficient was performed. Results: After adjusting cognitive scores by age, anxiety and EDSS, association was detected between CHI3L1 levels and Trail Making Test A (r s = 0.348; p = 0.016) and between NF-L levels and Word List Generation (r s = −0.324; p = 0.025). Conclusion: High levels of CSF CHI3L1 and NF-L are associated with cognitive impairment in the early phases of MS.

AB - © 2018 EAN Background and purpose: Chitinase 3-like 1 (CHI3L1) and neurofilament light chain (NF-L) are promising biomarkers of disability in multiple sclerosis (MS). However, their role in cognitive dysfunction remains elusive. Here, we aimed to correlate cerebrospinal fluid (CSF) levels of CHI3L1 and NF-L with cognitive status in MS. Methods: Fifty one recently diagnosed patients were cognitively evaluated and CSF was collected. Levels of CHI3L1 and NF-L were determined by ELISA. Spearman's partial correlation coefficient was performed. Results: After adjusting cognitive scores by age, anxiety and EDSS, association was detected between CHI3L1 levels and Trail Making Test A (r s = 0.348; p = 0.016) and between NF-L levels and Word List Generation (r s = −0.324; p = 0.025). Conclusion: High levels of CSF CHI3L1 and NF-L are associated with cognitive impairment in the early phases of MS.

KW - biomarkers

KW - chitinase 3-like 1

KW - mild cognitive impairment

KW - multiple sclerosis

KW - neurofilament light chain

U2 - 10.1111/ene.13687

DO - 10.1111/ene.13687

M3 - Article

VL - 25

SP - 1189

EP - 1191

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 9

ER -