Abstract
© 2018 EAN Background and purpose: Chitinase 3-like 1 (CHI3L1) and neurofilament light chain (NF-L) are promising biomarkers of disability in multiple sclerosis (MS). However, their role in cognitive dysfunction remains elusive. Here, we aimed to correlate cerebrospinal fluid (CSF) levels of CHI3L1 and NF-L with cognitive status in MS. Methods: Fifty one recently diagnosed patients were cognitively evaluated and CSF was collected. Levels of CHI3L1 and NF-L were determined by ELISA. Spearman's partial correlation coefficient was performed. Results: After adjusting cognitive scores by age, anxiety and EDSS, association was detected between CHI3L1 levels and Trail Making Test A (r s = 0.348; p = 0.016) and between NF-L levels and Word List Generation (r s = −0.324; p = 0.025). Conclusion: High levels of CSF CHI3L1 and NF-L are associated with cognitive impairment in the early phases of MS.
Original language | English |
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Pages (from-to) | 1189-1191 |
Journal | European Journal of Neurology |
Volume | 25 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1 Sep 2018 |
Keywords
- biomarkers
- chitinase 3-like 1
- mild cognitive impairment
- multiple sclerosis
- neurofilament light chain