Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain

E. Quintana, C. Coll, J. Salavedra-Pont, M. Muñoz-San Martín, R. Robles-Cedeño, J. Tomàs-Roig, M. Buxó, C. Matute-Blanch, L. M. Villar, X. Montalban, M. Comabella, H. Perkal, J. Gich, L. Ramió-Torrentà

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20 Citations (Scopus)

Abstract

© 2018 EAN Background and purpose: Chitinase 3-like 1 (CHI3L1) and neurofilament light chain (NF-L) are promising biomarkers of disability in multiple sclerosis (MS). However, their role in cognitive dysfunction remains elusive. Here, we aimed to correlate cerebrospinal fluid (CSF) levels of CHI3L1 and NF-L with cognitive status in MS. Methods: Fifty one recently diagnosed patients were cognitively evaluated and CSF was collected. Levels of CHI3L1 and NF-L were determined by ELISA. Spearman's partial correlation coefficient was performed. Results: After adjusting cognitive scores by age, anxiety and EDSS, association was detected between CHI3L1 levels and Trail Making Test A (r s = 0.348; p = 0.016) and between NF-L levels and Word List Generation (r s = −0.324; p = 0.025). Conclusion: High levels of CSF CHI3L1 and NF-L are associated with cognitive impairment in the early phases of MS.
Original languageEnglish
Pages (from-to)1189-1191
JournalEuropean Journal of Neurology
Volume25
Issue number9
DOIs
Publication statusPublished - 1 Sep 2018

Keywords

  • biomarkers
  • chitinase 3-like 1
  • mild cognitive impairment
  • multiple sclerosis
  • neurofilament light chain

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