Cognitive event-related brain potentials (P300) in patients with normal pressure hydrocephalus. Results of a prospective study

M. D. de la Calzada, M. A. Poca, J. Sahuquillo, M. Matarín, M. Mataró, E. Solana

    Research output: Contribution to journalArticleResearchpeer-review

    2 Citations (Scopus)

    Abstract

    Objective: To determine the response to cognitive event-related potentials (P300) in patients with normal-pressure hydrocephalus (NPH) and their relationship with clinical and cognitive status before and after shunt surgery. Methods: We performed a prospective study in a series of 26 patients with NPH who underwent clinical and cognitive assessment before surgery and 6 months afterwards. Visual P300 potentials obtained before and after treatment were also compared with those obtained in 18 healthy volunteers. Results: Before shunting, the P300 wave was detected in 11 (42.3%) NPH patients, compared with the 18 (100%) volunteers. Six months after shunting, the P300 wave was found in 20 (76.9%) NPH patients. P300 latency was significantly longer in NPH patients than in the control group before surgery, but not at 6 months after surgery. No significant differences in neuropsychological studies or in the level of dependence for daily life activities were found between the subgroups of NPH patients with and without pre-surgical P300 waves, or between changes in P300 parameters and clinical and cognitive changes. Conclusions: The P300 wave was delayed or undetectable in a substantial percentage of patients with NPH before surgery. These alterations can be reversed by shunting. P300 analysis and neuropsychological tests could be complementary measures to evaluate functional status in patients with NPH. © 2010 Sociedad Española de Neurología.
    Original languageEnglish
    Pages (from-to)32-39
    JournalNeurologia
    Volume25
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2010

    Keywords

    • Cognitive event-related brain potentials
    • Neuropsychology
    • Normal pressure hydrocephalus
    • P300
    • Visual event-related potentials

    Fingerprint Dive into the research topics of 'Cognitive event-related brain potentials (P300) in patients with normal pressure hydrocephalus. Results of a prospective study'. Together they form a unique fingerprint.

    Cite this