Cognitive disturbances and neuropsychological changes after surgical treatment in a cohort of 185 patients with idiopathic normal pressure hydrocephalus

Elisabeth Solana, Juan Sahuquillo, Carme Junqué, Manuel Quintana, Maria A. Poca

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    21 Citations (Scopus)

    Abstract

    Although idiopathic normal pressure hydrocephalus (iNPH) is considered a treatable dementia, there is still some controversy regarding the cognitive improvement in these patients. The main aims of this study were to analyze baseline cognitive status and to study the neuropsychological changes after surgical treatment in a sample of 185 consecutive iNPH patients. An additional aim was to identify the variables that influenced the cognitive outcome. Specific tests assessing memory, attention, visual scanning, executive functions (EFs), and motor speed were used before and 6 months after shunting. The cognitive domains most affected at baseline were memory, EFs, attention, and psychomotor speed. After shunting, significant differences in the group as a whole were found in all tests except Digits Forward and Trail Making Part B. However, less than 50% of patients showed a significant improvement when analyzed individually. Previous global cognitive status assessed by Mini-Mental State Examination baseline scores was the best predictor for the cognitive outcome. © The Author 2012.
    Original languageEnglish
    Pages (from-to)304-317
    JournalArchives of Clinical Neuropsychology
    Volume27
    Issue number3
    DOIs
    Publication statusPublished - 1 May 2012

    Keywords

    • Cognitive outcome
    • Global cognitive status
    • Idiopathic normal pressure hydrocephalus
    • Neuropsychological assessment

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