Cognitive assessment protocol design in the ISSYS (Investigating Silent Strokes in hYpertensives: A magnetic resonance imaging Study)

I. Riba, C. I. Jarca, X. Mundet, J. L. Tovar, F. Orfila, C. Nafría, A. Raga, A. Girona, P. Fernández-Lara, X. Castañé, J. Álvarez Sabin, I. Fernández Cortiñas, O. Maisterra, J. Montaner, P. Delgado

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8 Citations (Scopus)

Abstract

Hypertension and silent cerebrovascular lesions (SCL) detected by brain magnetic resonance imaging (MRI) are associated with an increased risk of cognitive decline. In a prospective observational study in 1000 hypertensive patients, aged 50-70 years, with no prior history of stroke or dementia, we will study the presence of mild cognitive impairment (MCI) and the relationship between SCL and cognition. All participants will be assessed by means of the Dementia Rating Scale - 2 (DRS-2) and will undergo a brain MRI. In order to better characterize MCI and future dementia risk in our cohort, those patients that are suspected to be cognitively impaired according to the DRS-2 results will have a further neurological evaluation and complete neuropsychological testing. Follow-up for the entire cohort is planned to last for at least 3 years. © 2012 Elsevier B.V.
Original languageEnglish
Pages (from-to)79-81
JournalJournal of the Neurological Sciences
Volume322
Issue number1-2
DOIs
Publication statusPublished - 15 Nov 2012

Keywords

  • Dementia
  • Hypertension
  • Mild cognitive impairment
  • Silent cerebrovascular lesions

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