Cocoa, hazelnuts, sterols and soluble fiber cream reduces lipids and inflammation biomarkers in hypertensive patients: A randomized controlled trial

Rosa Solà, Rosa M. Valls, Gemma Godàs, Gloria Perez-Busquets, Josep Ribalta, Josefa Girona, Mercedes Heras, Antoni Castro, Gema Domenech, Ferran Torres, Lluís Masana, Neus Anglés, Jordi Reguant, Bartolomé Ramírez, Joaquim M. Barriach, Anna Cabré (Sant Pau)

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    Abstract

    Background: Cocoa, mixed with other food ingredients, intake can have beneficial effects on cardiovascular disease (CVD) biomarkers. We compared the effects of 4 cocoa cream products on some of these biomarkers. Methods and Findings: In this multi-centered, randomized, controlled, double-blind, parallel trial, volunteers (n = 113; age range: 43-65 years) who were pre-hypertensive, stage-1 hypertensive and hypercholesterolemic received one of 4 cocoa cream products (13 g/unit; 1 g cocoa/unit, 6 units/d; 465 Kcal/d) added to a low saturated fat diet for 4 weeks. The groups were: A) (n = 28), cocoa cream considered as control; B) (n = 28), cocoa+hazelnut cream (30 g/d hazelnuts); C) (n = 30), cocoa+hazelnuts+phytosterols (2 g/d); and D) (n = 27), cocoa+hazelnuts+phytosterols+soluble fiber (20 g/d) the patented "LMN product". Primary outcome measures were BP, LDL-c, apolipoprotein B-100 (Apo B), ApoB/ApoA ratio, oxidized LDL (oxLDL) and high-sensitive C-reactive protein (hsCRP) determined at baseline and post-cocoa cream product intake. Statistical analysis used was ANCOVA or mixed models (in case of repeated measurements), with baseline observation included as a covariate. After 4 weeks, compared to product A, product C reduced LDL-c by 11.2%, Apo B by 8.1% and ApoB/ApoA ratio by 7.8% (P = 0.01). LMN decreased LDL-c by 9.2%, Apo B-100 by 8.5%, ApoB/ApoA ratio by 10.5%, hsCRP by 33.4% and oxLDL by 5.9% (P = 0.01). Surprisingly, even "control" product A reduced systolic BP (-7.89 mmHg; 95%CI: -11.45 to -4.3) and diastolic BP (-5.54 mmHg; 95%CI: -7.79 to -3.29). The BP reductions were similar with the other 3 products. Limitations of the study are that the trial period was relatively short and that a better "BP control" product would have been preferable. Conclusion: The creams (particularly the LMN) have anti-inflammatory and antioxidant effects in addition to lowering LDL-c, Apo B and ApoB/ApoA ratio. Thus, the soluble fiber effects amplified with sterols (as contained in the cocoa creams) provide new dietary therapeutic perspectives. © 2012 Solà et al.
    Original languageEnglish
    Article numbere31103
    JournalPLoS ONE
    Volume7
    Issue number2
    DOIs
    Publication statusPublished - 27 Feb 2012

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    Solà, R., Valls, R. M., Godàs, G., Perez-Busquets, G., Ribalta, J., Girona, J., Heras, M., Castro, A., Domenech, G., Torres, F., Masana, L., Anglés, N., Reguant, J., Ramírez, B., Barriach, J. M., & Cabré (Sant Pau), A. (2012). Cocoa, hazelnuts, sterols and soluble fiber cream reduces lipids and inflammation biomarkers in hypertensive patients: A randomized controlled trial. PLoS ONE, 7(2), [e31103]. https://doi.org/10.1371/journal.pone.0031103