TY - JOUR
T1 - Cocaine-induced psychosis and brain-derived neurothrophic factor in patients with cocaine dependence: Report of two cases
AU - Roncero, Carlos
AU - Palma-Álvarez, Raul Felipe
AU - Ros-Cucurull, Elena
AU - Barral, Carmen
AU - Gonzalvo, Begoña
AU - Corominas-Roso, Margarida
AU - Casas, Miguel
AU - Grau-López, Lara
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Copyright © 2016, Korean College of Neuropsychopharmacology. Brain-derived neurotrophic factor (BDNF) is linked to numerous brain functions. In addition, BDNF alterations contribute to neurological, mental, and addictive disorders. Cocaine dependence has received much attention recently due to its prevalence and psychological effects. Symptoms of psychosis are one of the most serious adverse events precipitated by cocaine use. It is particularly important to identify patients at risk of developing cocaine-induced psychosis (CIP). We described two cases of patients with cocaine dependence who presented with CIP and had changes in their BDNF levels during the psychotic episode. BDNF levels were initially low in both patients, and then decreased by more than 50% in association with CIP. The relationship between BDNF and psychosis is described in the literature. These cases revealed that BDNF levels decreased during a CIP episode and, thus, it is necessary to investigate BDNF and its relationship with CIP further.
AB - Copyright © 2016, Korean College of Neuropsychopharmacology. Brain-derived neurotrophic factor (BDNF) is linked to numerous brain functions. In addition, BDNF alterations contribute to neurological, mental, and addictive disorders. Cocaine dependence has received much attention recently due to its prevalence and psychological effects. Symptoms of psychosis are one of the most serious adverse events precipitated by cocaine use. It is particularly important to identify patients at risk of developing cocaine-induced psychosis (CIP). We described two cases of patients with cocaine dependence who presented with CIP and had changes in their BDNF levels during the psychotic episode. BDNF levels were initially low in both patients, and then decreased by more than 50% in association with CIP. The relationship between BDNF and psychosis is described in the literature. These cases revealed that BDNF levels decreased during a CIP episode and, thus, it is necessary to investigate BDNF and its relationship with CIP further.
KW - Biological marker
KW - Brain-derived neurotrophic factor
KW - Cocaine dependence
KW - Cocaine-induced psychosis
KW - Psychosis
U2 - 10.9758/cpn.2016.14.1.109
DO - 10.9758/cpn.2016.14.1.109
M3 - Article
SN - 1738-1088
VL - 14
SP - 109
EP - 113
JO - Clinical Psychopharmacology and Neuroscience
JF - Clinical Psychopharmacology and Neuroscience
IS - 1
ER -