Cobalt mediated regioselective alkylation of methyl 3,5-dioxohexanote. Preparation of 5-alkyl derivatives of 4-hydroxy-6-methyl-2-pyrone

Jordi Cervelló, Jorge Marquet, Marcial Moreno-Mañas

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Abstract

The cobalt(II) complex of the simple polyketide model methyl 3,5-dioxohexanoate is regioselectively alkylated to afford methyl 4-alkyl-3,5-dioxohexanoates, which cyclize on treatment with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to give 5-alkyl-4-hydroxy-6-methyl-2- pyrones.
Original languageEnglish
Pages (from-to)644-645
JournalJournal of the Chemical Society, Chemical Communications
Issue number9
DOIs
Publication statusPublished - 1 Dec 1987

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