TY - JOUR
T1 - Cobalt-mediated alkylation of (4R) and (4S)-3-acetoacetyl-4-benzyloxazolidin-2-ones. Preparation of enantiopure diphenylmethyl-, 9-fluorenyl-, and (1-adamantyl)glycines
AU - Gálvez, Nicanor
AU - Moreno-Mañas, Marcial
AU - Vallribera, Adelina
AU - Molins, Elies
AU - Cabrero, Araceli
PY - 1996/8/19
Y1 - 1996/8/19
N2 - The Co(II) complexes of (4R) and (4S)-3-acetoacetyl-4-benzyloxazolidin-2-ones are alkylated diastereoselectively with diphenylmethyl, 9-fluorenyl, and 1-adamantyl bromide. The resulting products are converted into enantiopure α-substituted glycines. Similar results are obtained by alkylation of the free acetoacetyloxazolidinones under Co(II)-catalysis.
AB - The Co(II) complexes of (4R) and (4S)-3-acetoacetyl-4-benzyloxazolidin-2-ones are alkylated diastereoselectively with diphenylmethyl, 9-fluorenyl, and 1-adamantyl bromide. The resulting products are converted into enantiopure α-substituted glycines. Similar results are obtained by alkylation of the free acetoacetyloxazolidinones under Co(II)-catalysis.
U2 - 10.1016/0040-4039(96)01322-6
DO - 10.1016/0040-4039(96)01322-6
M3 - Article
VL - 37
SP - 6197
EP - 6200
IS - 34
ER -