Coated Cotton Fabrics with Antibacterial and Anti-Inflammatory Silica Nanoparticles for Improving Wound Healing

Ming Liu; Axel Guinart Guillem; Albert Granados Toda; Carolina Gimbert Suriñach; Ester Fernandez; Roser Pleixats i Rovira; Adelina Vallribera Massó

doi:10.1021/acsami.4c00383

Coated Cotton Fabrics with Antibacterial and Anti-Inflammatory Silica Nanoparticles for Improving Wound Healing

Ming Liu, Axel Guinart Guillem, Albert Granados Toda, Carolina Gimbert Suriñach, Ester Fernandez, Roser Pleixats i Rovira, Adelina Vallribera Massó

Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)

Abstract

Herein, we report the preparation of bifunctional silica nanoparticles by covalent attachment of both an anti-inflammatory drug (ibuprofen) and an antibiotic (levofloxacin or norfloxacin) through amide groups. We also describe the coating of cotton fabrics with silica nanoparticles containing both ibuprofen and norfloxacin moieties linked by amide groups by using a one-step coating procedure under ultrasonic conditions. The functionalized nanoparticles and cotton fabrics have been characterized using spectroscopic and microscopic techniques. The functionalized nanoparticles and textiles have been treated with model proteases for the in situ release of the drugs by the amide bond enzymatic cleavage. Topical dermal applications in medical bandages are expected, which favor wound healing.

Original language	English
Pages (from-to)	14595-14604
Number of pages	10
Journal	ACS applied materials & interfaces
Volume	16
Issue number	12
DOIs	https://doi.org/10.1021/acsami.4c00383
Publication status	Published - 12 Mar 2024

Keywords

amide groups
anti-inflammatory
antimicrobial
cotton wound dressing
enzymatic cleavage
ibuprofen
norfloxacin
silica nanoparticles

Access to Document

10.1021/acsami.4c00383

https://ddd.uab.cat/record/291542

Cite this

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title = "Coated Cotton Fabrics with Antibacterial and Anti-Inflammatory Silica Nanoparticles for Improving Wound Healing",

abstract = "Herein, we report the preparation of bifunctional silica nanoparticles by covalent attachment of both an anti-inflammatory drug (ibuprofen) and an antibiotic (levofloxacin or norfloxacin) through amide groups. We also describe the coating of cotton fabrics with silica nanoparticles containing both ibuprofen and norfloxacin moieties linked by amide groups by using a one-step coating procedure under ultrasonic conditions. The functionalized nanoparticles and cotton fabrics have been characterized using spectroscopic and microscopic techniques. The functionalized nanoparticles and textiles have been treated with model proteases for the in situ release of the drugs by the amide bond enzymatic cleavage. Topical dermal applications in medical bandages are expected, which favor wound healing.",

keywords = "amide groups, anti-inflammatory, antimicrobial, cotton wound dressing, enzymatic cleavage, ibuprofen, norfloxacin, silica nanoparticles",

author = "Ming Liu and {Guinart Guillem}, Axel and {Granados Toda}, Albert and {Gimbert Suri{\~n}ach}, Carolina and Ester Fernandez and {Pleixats i Rovira}, Roser and {Vallribera Mass{\'o}}, Adelina",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors. Published by American Chemical Society",

year = "2024",

month = mar,

day = "12",

doi = "10.1021/acsami.4c00383",

language = "English",

volume = "16",

pages = "14595--14604",

journal = "ACS applied materials & interfaces",

issn = "1944-8252",

publisher = "American Chemical Society",

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T1 - Coated Cotton Fabrics with Antibacterial and Anti-Inflammatory Silica Nanoparticles for Improving Wound Healing

AU - Liu, Ming

AU - Guinart Guillem, Axel

AU - Granados Toda, Albert

AU - Gimbert Suriñach, Carolina

AU - Fernandez, Ester

AU - Pleixats i Rovira, Roser

AU - Vallribera Massó, Adelina

PY - 2024/3/12

Y1 - 2024/3/12

N2 - Herein, we report the preparation of bifunctional silica nanoparticles by covalent attachment of both an anti-inflammatory drug (ibuprofen) and an antibiotic (levofloxacin or norfloxacin) through amide groups. We also describe the coating of cotton fabrics with silica nanoparticles containing both ibuprofen and norfloxacin moieties linked by amide groups by using a one-step coating procedure under ultrasonic conditions. The functionalized nanoparticles and cotton fabrics have been characterized using spectroscopic and microscopic techniques. The functionalized nanoparticles and textiles have been treated with model proteases for the in situ release of the drugs by the amide bond enzymatic cleavage. Topical dermal applications in medical bandages are expected, which favor wound healing.

AB - Herein, we report the preparation of bifunctional silica nanoparticles by covalent attachment of both an anti-inflammatory drug (ibuprofen) and an antibiotic (levofloxacin or norfloxacin) through amide groups. We also describe the coating of cotton fabrics with silica nanoparticles containing both ibuprofen and norfloxacin moieties linked by amide groups by using a one-step coating procedure under ultrasonic conditions. The functionalized nanoparticles and cotton fabrics have been characterized using spectroscopic and microscopic techniques. The functionalized nanoparticles and textiles have been treated with model proteases for the in situ release of the drugs by the amide bond enzymatic cleavage. Topical dermal applications in medical bandages are expected, which favor wound healing.

KW - amide groups

KW - anti-inflammatory

KW - antimicrobial

KW - cotton wound dressing

KW - enzymatic cleavage

KW - ibuprofen

KW - norfloxacin

KW - silica nanoparticles

UR - http://www.scopus.com/inward/record.url?scp=85187569992&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/0e8c2a92-0f3d-3fec-a1a3-b65d7bc5b023/

U2 - 10.1021/acsami.4c00383

DO - 10.1021/acsami.4c00383

M3 - Article

C2 - 38469717

SN - 1944-8252

VL - 16

SP - 14595

EP - 14604

JO - ACS applied materials & interfaces

JF - ACS applied materials & interfaces

IS - 12

ER -

Coated Cotton Fabrics with Antibacterial and Anti-Inflammatory Silica Nanoparticles for Improving Wound Healing

Abstract

Keywords

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EMERGENT (PER)FLUORINATION METHODS. PHOTOCATALYSIS

ORGANIC MOLECULES AND MATERIALS FOR CATALYTIC SUNLIGHT DRIVEN REACTIONS

QUIMICA ORGANOFLUORADA: METODOS EMERGENTES DE FLUORACION Y TEJIDOS DE ALGODON PARA USOS MEDICOS

Cite this

Coated Cotton Fabrics with Antibacterial and Anti-Inflammatory Silica Nanoparticles for Improving Wound Healing

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Projects

EMERGENT (PER)FLUORINATION METHODS. PHOTOCATALYSIS

ORGANIC MOLECULES AND MATERIALS FOR CATALYTIC SUNLIGHT DRIVEN REACTIONS

QUIMICA ORGANOFLUORADA: METODOS EMERGENTES DE FLUORACION Y TEJIDOS DE ALGODON PARA USOS MEDICOS

Cite this