Co-factor-enhanced food allergy

V. Cardona, O. Luengo, T. Garriga, M. Labrador-Horrillo, A. Sala-Cunill, A. Izquierdo, L. Soto, M. Guilarte

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101 Citations (Scopus)


Background: Alcohol, exercise or non-steroidal anti-inflamatory drugs (NSAID) are frequently mentioned as amplifiers of food allergic reactions but only individual cases or small series have been previously published. Methods: Descriptive study including 74 cases of suspected co-factor enhanced food allergy, assessed by skin-prick tests, specific IgE and oral challenges. Results: Anaphylaxis accounted for 85.1% of reactions. In 99% of cases culprit food allergens were plant-derived, mainly vegetables and cereals. NSAID were involved in 58%, exercise in 52.7% and alcohol in 12.2%. Lipid transfer protein was the most frequently involved allergen. Conclusions: Co-factor enhanced food allergy should be considered when assessing food, alcohol, exercise and NSAID allergic reactions. © 2012 John Wiley & Sons A/S.
Original languageEnglish
Pages (from-to)1316-1318
JournalAllergy: European Journal of Allergy and Clinical Immunology
Issue number10
Publication statusPublished - 1 Jan 2012


  • anaphylaxis
  • co-factor
  • exercise
  • food allergy
  • nonsteroidal anti-inflammatory drugs


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