Cloning and sequence of the gene encoding a novel cefotaxime-hydrolyzing β-lactamase (CTX-M-9) from Escherichia coli in Spain

Montserrat Sabaté, Raül Tarragó, Ferran Navarro, Elisenda Miró, Clara Vergés, Jordi Barbé, Guillermo Prats

Research output: Contribution to journalArticleResearchpeer-review

123 Citations (Scopus)

Abstract

A new CTX-M-type β-lactamase (CTX-M-9) has been cloned from a clinical cefotaxime-resistant Escherichia coli strain. Despite the close identity that exists between the CTX-M-9 and Toho-2 β-lactamases (88%), the 35 amino acids located between residues Ala-185 and Ala-219 are totally different in both enzymes. Outside of this region there are only six amino acids substitutions between both proteins.
Original languageEnglish
Pages (from-to)1970-1973
JournalAntimicrobial Agents and Chemotherapy
Volume44
DOIs
Publication statusPublished - 1 Jul 2000

Fingerprint Dive into the research topics of 'Cloning and sequence of the gene encoding a novel cefotaxime-hydrolyzing β-lactamase (CTX-M-9) from Escherichia coli in Spain'. Together they form a unique fingerprint.

Cite this