Cloning and analysis of the coding region of the histone H1° -encoding gene from rat PC12 cells

Pedro Martinez, JoséM M. Vidal, Claudio Monsalves, Mercè Pérez, Carmie Pucket, Imma Ponte, Pedro Suau

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

We have determined the complete coding sequence of the histone-encoding H1° gene from rat PC12 cells. Southern and Northern analyses suggest that rat H1° is encoded by a single-copy gene which generates an mRNA of about 2.2 kb. Comparison of the rat, mouse and human amino-acid sequences shows that the C-terminal domain of the protein is much more variable than the N-terminal and central domains. Rates of non-synonymous and synonymous nucleotide substitution have been calculated. The rate of non-synonymous substitution is about 2.5-times higher in the rodent lineage than in the human lineage. © 1995.
Original languageEnglish
Pages (from-to)313-316
JournalGene
Volume166
DOIs
Publication statusPublished - 12 Dec 1995

Keywords

  • Non-synonymous substitution
  • molecular evolution
  • neuron

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