CLIP-HSQMBC: Easy measurement of small proton-carbon coupling constants in organic molecules

Josep Saurí, Teodor Parella, Juan F. Espinosa

    Research output: Contribution to journalArticleResearchpeer-review

    28 Citations (Scopus)

    Abstract

    A user-friendly 2D NMR approach denoted as CLIP-HSQMBC is proposed for the very easy, direct and accurate measurement of long-range proton-carbon coupling constants in organic molecules and natural products. The J value can be extracted directly from the analysis of resolved in-phase 1H multiplets that show an additional splitting arising from the proton-carbon coupling. In cases of unresolved peaks, a simple fitting analysis using the internal satellite lines as a reference is performed. Addition of a spin-lock period results in a CLIP-HSQMBC-TOCSY experiment that is suitable for the measurement of very small coupling values or to observe correlations from overlapped resonances. © The Royal Society of Chemistry 2013.
    Original languageEnglish
    Pages (from-to)4473-4478
    JournalOrganic and Biomolecular Chemistry
    Volume11
    Issue number27
    DOIs
    Publication statusPublished - 21 Jul 2013

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