Clinical Value of Thyrotropin Receptor Antibodies for the Differential Diagnosis of Interferon Induced Thyroiditis

D. Benaiges, M. Garcia-Retortillo, A. Mas, N. Cañete, T. Broquetas, M. Puigvehi, J. J. Chillarón, J. A. Flores-Le Roux, E. Sagarra, B. Cabrero, D. Zaffalon, R. Solà, J. Pedro-Botet, J. A. Carrión

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Abstract

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart·New York. Objective: The clinical value of thyrotropin receptor antibodies for the differential diagnosis of thyrotoxicosis induced by pegylated interferon-alpha remains unknown. We analyzed the diagnostic accuracy of thyrotropin receptor antibodies in the differential diagnosis of thyrotoxicosis in patients with chronic hepatitis C (CHC) receiving pegylated interferon-alpha plus ribavirin. Methods: Retrospective analysis of 274 patients with CHC receiving pegylated interferon-alpha plus ribavirin. Interferon-induced thyrotoxicosis was classified according to clinical guidelines as Graves disease, autoimmune and non- autoimmune destructive thyroiditis. Results: 48 (17.5%) patients developed hypothyroidism, 17 (6.2%) thyrotoxicosis (6 non- autoimmune destructive thyroiditis, 8 autoimmune destructive thyroiditis and 3 Graves disease) and 22 de novo thyrotropin receptor antibodies (all Graves disease, 2 of the 8 autoimmune destructive thyroiditis and 17 with normal thyroid function). The sensitivity and specificity of thyrotropin receptor antibodies for Graves disease diagnosis in patients with thyrotoxicosis were 100 and 85%, respectively. Patients with destructive thyroiditis developed hypothyroidism in 87.5% of autoimmune cases and in none of those with a non- autoimmune etiology (p<0.001). Conclusion: Thyrotropin receptor antibodies determination cannot replace thyroid scintigraphy for the differential diagnosis of thyrotoxicosis in CHC patients treated with pegylated interferon.
Original languageEnglish
Pages (from-to)39-44
JournalExperimental and Clinical Endocrinology and Diabetes
Volume124
Issue number1
DOIs
Publication statusPublished - 17 Nov 2015

Keywords

  • Graves-disease
  • interferon induced thyroiditis
  • pegylated interferon-alpha
  • thyroid-stimulating immunoglobulins

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