TY - JOUR
T1 - Clinical status of motoneuron disease does not correlate with serum neurotoxicity on cultured neurons
AU - Marti‐Fàbregas, J.
AU - Soler, R.
AU - Esquerda, J.
AU - Ma Grau, J.
AU - Prada, J.
AU - Illa, I.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - To test the hypothesis that a serum factor may be toxic to motoneurons in Motoneuron disease (MND), we evaluated neuronal survival in dissociated cultures from chick ciliary ganglia neurons in which MND or control sera were applied. No neurotoxic activity was found when comparing neuronal survival at 1 and 3 days in MND and control group. To examine the influence of the clinical MND status on neuronal survival, we used the following parameters: age at onset, sex, months from onset of disease to sera sampling, MND form, rhythm of progression, and scoring with Appel scale. No effect was noted for any of these factors. Sera from the same patient obtained at different clinical stages did not allow any conclusion of a fixed behavior for the same patient. Our findings argue against the existence of a cytotoxic factor in sera from MND patients. Copyright © 1992, Wiley Blackwell. All rights reserved
AB - To test the hypothesis that a serum factor may be toxic to motoneurons in Motoneuron disease (MND), we evaluated neuronal survival in dissociated cultures from chick ciliary ganglia neurons in which MND or control sera were applied. No neurotoxic activity was found when comparing neuronal survival at 1 and 3 days in MND and control group. To examine the influence of the clinical MND status on neuronal survival, we used the following parameters: age at onset, sex, months from onset of disease to sera sampling, MND form, rhythm of progression, and scoring with Appel scale. No effect was noted for any of these factors. Sera from the same patient obtained at different clinical stages did not allow any conclusion of a fixed behavior for the same patient. Our findings argue against the existence of a cytotoxic factor in sera from MND patients. Copyright © 1992, Wiley Blackwell. All rights reserved
KW - amyotrophic lateral sclerosis
KW - cells culture
KW - motor neuron disease
KW - motor neurons
KW - trophic factors
U2 - 10.1111/j.1600-0404.1992.tb04032.x
DO - 10.1111/j.1600-0404.1992.tb04032.x
M3 - Article
VL - 85
SP - 219
EP - 223
JO - Acta Neurologica Scandinavica
JF - Acta Neurologica Scandinavica
SN - 0001-6314
IS - 3
ER -