Clinical status of motoneuron disease does not correlate with serum neurotoxicity on cultured neurons

J. Marti‐Fàbregas; R. Soler; J. Esquerda; J. Ma Grau; J. Prada; I. Illa

doi:10.1111/j.1600-0404.1992.tb04032.x

Clinical status of motoneuron disease does not correlate with serum neurotoxicity on cultured neurons

J. Marti‐Fàbregas, R. Soler, J. Esquerda, J. Ma Grau, J. Prada, I. Illa

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

To test the hypothesis that a serum factor may be toxic to motoneurons in Motoneuron disease (MND), we evaluated neuronal survival in dissociated cultures from chick ciliary ganglia neurons in which MND or control sera were applied. No neurotoxic activity was found when comparing neuronal survival at 1 and 3 days in MND and control group. To examine the influence of the clinical MND status on neuronal survival, we used the following parameters: age at onset, sex, months from onset of disease to sera sampling, MND form, rhythm of progression, and scoring with Appel scale. No effect was noted for any of these factors. Sera from the same patient obtained at different clinical stages did not allow any conclusion of a fixed behavior for the same patient. Our findings argue against the existence of a cytotoxic factor in sera from MND patients. Copyright © 1992, Wiley Blackwell. All rights reserved

Original language	English
Pages (from-to)	219-223
Journal	Acta Neurologica Scandinavica
Volume	85
Issue number	3
DOIs	https://doi.org/10.1111/j.1600-0404.1992.tb04032.x
Publication status	Published - 1 Jan 1992

Keywords

amyotrophic lateral sclerosis
cells culture
motor neuron disease
motor neurons
trophic factors

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title = "Clinical status of motoneuron disease does not correlate with serum neurotoxicity on cultured neurons",

abstract = "To test the hypothesis that a serum factor may be toxic to motoneurons in Motoneuron disease (MND), we evaluated neuronal survival in dissociated cultures from chick ciliary ganglia neurons in which MND or control sera were applied. No neurotoxic activity was found when comparing neuronal survival at 1 and 3 days in MND and control group. To examine the influence of the clinical MND status on neuronal survival, we used the following parameters: age at onset, sex, months from onset of disease to sera sampling, MND form, rhythm of progression, and scoring with Appel scale. No effect was noted for any of these factors. Sera from the same patient obtained at different clinical stages did not allow any conclusion of a fixed behavior for the same patient. Our findings argue against the existence of a cytotoxic factor in sera from MND patients. Copyright {\textcopyright} 1992, Wiley Blackwell. All rights reserved",

keywords = "amyotrophic lateral sclerosis, cells culture, motor neuron disease, motor neurons, trophic factors",

author = "J. Marti‐F{\`a}bregas and R. Soler and J. Esquerda and {Ma Grau}, J. and J. Prada and I. Illa",

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AU - Marti‐Fàbregas, J.

AU - Soler, R.

AU - Esquerda, J.

AU - Ma Grau, J.

AU - Prada, J.

AU - Illa, I.

PY - 1992/1/1

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N2 - To test the hypothesis that a serum factor may be toxic to motoneurons in Motoneuron disease (MND), we evaluated neuronal survival in dissociated cultures from chick ciliary ganglia neurons in which MND or control sera were applied. No neurotoxic activity was found when comparing neuronal survival at 1 and 3 days in MND and control group. To examine the influence of the clinical MND status on neuronal survival, we used the following parameters: age at onset, sex, months from onset of disease to sera sampling, MND form, rhythm of progression, and scoring with Appel scale. No effect was noted for any of these factors. Sera from the same patient obtained at different clinical stages did not allow any conclusion of a fixed behavior for the same patient. Our findings argue against the existence of a cytotoxic factor in sera from MND patients. Copyright © 1992, Wiley Blackwell. All rights reserved

AB - To test the hypothesis that a serum factor may be toxic to motoneurons in Motoneuron disease (MND), we evaluated neuronal survival in dissociated cultures from chick ciliary ganglia neurons in which MND or control sera were applied. No neurotoxic activity was found when comparing neuronal survival at 1 and 3 days in MND and control group. To examine the influence of the clinical MND status on neuronal survival, we used the following parameters: age at onset, sex, months from onset of disease to sera sampling, MND form, rhythm of progression, and scoring with Appel scale. No effect was noted for any of these factors. Sera from the same patient obtained at different clinical stages did not allow any conclusion of a fixed behavior for the same patient. Our findings argue against the existence of a cytotoxic factor in sera from MND patients. Copyright © 1992, Wiley Blackwell. All rights reserved

KW - amyotrophic lateral sclerosis

KW - cells culture

KW - motor neuron disease

KW - motor neurons

KW - trophic factors

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DO - 10.1111/j.1600-0404.1992.tb04032.x

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