TY - JOUR
T1 - Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes
AU - Sepúlveda, Maria
AU - Armangue, Thaís
AU - Martinez-Hernandez, Eugenia
AU - Arrambide, Georgina
AU - Sola-Valls, Nuria
AU - Sabater, Lidia
AU - Téllez, Nieves
AU - Midaglia, Luciana
AU - Ariño, Helena
AU - Peschl, Patrick
AU - Reindl, Markus
AU - Rovira, Alex
AU - Montalban, Xavier
AU - Blanco, Yolanda
AU - Dalmau, Josep
AU - Graus, Francesc
AU - Saiz, Albert
PY - 2016/7/1
Y1 - 2016/7/1
N2 - © 2016, Springer-Verlag Berlin Heidelberg. The aim of this study was to report the clinical spectrum associated with antibodies to myelin oligodendrocyte glycoprotein (MOG) in adult patients, and to assess whether phenotypic variants are dependent on recognition of rodent MOG epitopes. We retrospectively analyzed the features, course and outcome of 56 patients whose samples were investigated by brain tissue immunohistochemistry and cell-based assays using human and rodent MOG. The median age at symptom onset was 37 years (range 18–70); 35 patients (63 %) were female. After a median follow-up of 43 months (range 4–554), only 14 patients (25 %) developed a neuromyelitis optica spectrum disorder (NMOSD), 27 patients (47 %) retained the initial diagnosis of isolated optic neuritis, 7 (12 %) of longitudinally extensive transverse myelitis, and 2 (4 %) of acute disseminated encephalomyelitis; 6 patients (11 %) developed atypical demyelinating syndromes (4 had relapsing episodes of short myelitis lesions which in one occurred with optic neuritis; 1 had relapsing brainstem symptoms, and 1 relapsing demyelinating encephalomyelitis). The course was frequently associated with relapses (71 %) and good outcome. Twenty-seven patients (49 %) had antibodies that recognized rodent MOG epitopes, and 9 of them (16 %) showed a myelin staining pattern in rodent tissue. Only the myelin staining pattern was linked to NMOSD (p = 0.005). In conclusion, MOG autoimmunity in adult patients associates with a clinical spectrum wider than the one expected for patients with suspected NMOSD and overall good outcome. Antibodies to rodent MOG epitopes do not associate with any phenotypic variant.
AB - © 2016, Springer-Verlag Berlin Heidelberg. The aim of this study was to report the clinical spectrum associated with antibodies to myelin oligodendrocyte glycoprotein (MOG) in adult patients, and to assess whether phenotypic variants are dependent on recognition of rodent MOG epitopes. We retrospectively analyzed the features, course and outcome of 56 patients whose samples were investigated by brain tissue immunohistochemistry and cell-based assays using human and rodent MOG. The median age at symptom onset was 37 years (range 18–70); 35 patients (63 %) were female. After a median follow-up of 43 months (range 4–554), only 14 patients (25 %) developed a neuromyelitis optica spectrum disorder (NMOSD), 27 patients (47 %) retained the initial diagnosis of isolated optic neuritis, 7 (12 %) of longitudinally extensive transverse myelitis, and 2 (4 %) of acute disseminated encephalomyelitis; 6 patients (11 %) developed atypical demyelinating syndromes (4 had relapsing episodes of short myelitis lesions which in one occurred with optic neuritis; 1 had relapsing brainstem symptoms, and 1 relapsing demyelinating encephalomyelitis). The course was frequently associated with relapses (71 %) and good outcome. Twenty-seven patients (49 %) had antibodies that recognized rodent MOG epitopes, and 9 of them (16 %) showed a myelin staining pattern in rodent tissue. Only the myelin staining pattern was linked to NMOSD (p = 0.005). In conclusion, MOG autoimmunity in adult patients associates with a clinical spectrum wider than the one expected for patients with suspected NMOSD and overall good outcome. Antibodies to rodent MOG epitopes do not associate with any phenotypic variant.
KW - Antibodies to myelin oligodendrocyte glycoprotein
KW - Cell-based assays
KW - Immunohistochemistry
KW - Longitudinally extensive myelitis
KW - MRI
KW - Neuromyelitis optica
KW - Optic neuritis
U2 - 10.1007/s00415-016-8147-7
DO - 10.1007/s00415-016-8147-7
M3 - Article
VL - 263
SP - 1349
EP - 1360
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
IS - 7
ER -