Clinical profile of patients with very high hypertriglyceridemia from the Registry of Hypertriglyceridemia of the Spanish Atherosclerosis Society

àngels Pedragosa, Jordi Merino, José L. Aranda, Jesús Galiana, Diego Godoy, Josefa M. Panisello, Juan F. Ascaso, Fernando Civeira, Luis Masana, Juan Pedro-Botet

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11 Citations (Scopus)

Abstract

Background and objective: To describe clinical and epidemiological characteristics of patients with very high hypertriglyceridemia (HTG) who were attended in lipid units of the Spanish Society of Atherosclerosis (SEA). Patients and method: Patients of the HTG Registry of SEA with at least one triglyceride concentration greater than 1,000. mg/dL (n=298, HTG severe group) and those whose baseline triglycerides were between 200 and 246. mg/dL (HTG control group, n=272) were included. Results: Patients with very high triglyceride levels were younger (46.9±11.5 years vs 52.7±13 years; p<0.0001), with a larger waist circumference (100.5±10.6 cm vs 98.5±11.1 cm; p=0.0426), higher alcohol intake (170.7±179.1. g/wk vs 118.8±106.4. g/wk; p=0,0473), active smoking status (45.6% vs 26.8%; p<0.0001) and a higher frequency of pancreatitis (10.2% vs 3%; p=0.0006) than HTG control group. There was a higher percentage of patients with atherogenic dietary pattern in severe HTG group compared with the control group (138 [46.3%] vs. 94 [34.5%]; p=0,001). The multivariate analysis showed that factors associated with a triglyceride concentration greater than 1,000. mg/dl were age, male sex, weight, waist circumference, alcohol, physical inactivity in non-business hours and the presence of diabetes mellitus. Conclusions: Patients with very high HTG were usually men in the fourth decade of life, with abdominal obesity, smoking and alcohol consumption. In 60% of cases the HTG was primary, and pancreatitis the most frequently complication. © 2012 Elsevier España, S.L. and SEA.
Original languageEnglish
Pages (from-to)8-15
JournalClinica e Investigacion en Arteriosclerosis
Volume25
Issue number1
DOIs
Publication statusPublished - 1 Jan 2013

Keywords

  • Cardiovascular disease
  • Hypertriglyceridemia
  • Metabolic syndrome
  • Pancreatitis
  • Registry
  • Therapy

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