Nonvariceal upper gastrointestinal (GI) bleeding is a common medical emergency associated with appreciable morbidity and mortality. The significant advances made in managing this condition in recent years have reduced the rates of rebleeding and mortality. These clinical guidelines for managing this emergency are intended to be highly practical, evidence-based, and take recent consensus statements into account. The 3 keys to managing nonvariceal upper GI bleeding are a) early restoration of fluids and blood pressure and the prevention of underlying cardiovascular disease, which is common in these patients; b) endoscopy to treat lesions at high risk of rebleeding; and c) medical therapy with high doses of proton pump inhibitors before and after endoscopy. These 3 measures, used in combination, reduce upper GI rebleeding and mortality rates.
|Publication status||Published - 1 Jan 2013|
- Acetylsalicylic acid (ASA)
- Gastric ulcer
- Helicobacter pylori
- Nonsteroidal antiinflammatory drugs (NSAIDs)
- Nonvariceal upper gastrointestinal bleeding
- Proton pump inhibitors