Clinical practice guidelines for managing nonvariceal upper gastrointestinal bleeding

Marta Gallach, Xavier Calvet, Ángel Lanas, Faust Feu, Julio Ponce, Javier P. Gisbert, Enric Brullet, Pascual Piñera, Manuel Castro, Carlos Martín De Argila, Enrique Domínguez Muñoz, Pedro Almela, Cándido Villanueva, Ángel González Galilea, Ángel Pérez Aisa, Pilar García-Iglesias, Emili Gené, Albert Villoria, Alan Barkun

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)


Nonvariceal upper gastrointestinal (GI) bleeding is a common medical emergency associated with appreciable morbidity and mortality. The significant advances made in managing this condition in recent years have reduced the rates of rebleeding and mortality. These clinical guidelines for managing this emergency are intended to be highly practical, evidence-based, and take recent consensus statements into account. The 3 keys to managing nonvariceal upper GI bleeding are a) early restoration of fluids and blood pressure and the prevention of underlying cardiovascular disease, which is common in these patients; b) endoscopy to treat lesions at high risk of rebleeding; and c) medical therapy with high doses of proton pump inhibitors before and after endoscopy. These 3 measures, used in combination, reduce upper GI rebleeding and mortality rates.
Original languageEnglish
Pages (from-to)472-481
Issue number6
Publication statusPublished - 1 Jan 2013


  • Acetylsalicylic acid (ASA)
  • Clopidogrel
  • Coagulation
  • Endoscopy
  • Gastric ulcer
  • Gastroscopy
  • Helicobacter pylori
  • Nonsteroidal antiinflammatory drugs (NSAIDs)
  • Nonvariceal upper gastrointestinal bleeding
  • Proton pump inhibitors
  • Recurrence


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