Clinical Manifestations and Outcomes of Syphilis-associated Uveitis in Northern Spain

Alex Fonollosa; Lorea Martinez-Indart; Joseba Artaraz; Agustin Martinez-Berriotxoa; Koldo Agirrebengoa; Miriam Garcia; Leire Lopez-Soria; Manuel Sorribas; David Diaz-Valle; Ricardo Blanco; Javier Rueda-Gotor; Alfredo Adan; Victor Llorenç; Miguel Cordero-Coma; Laura Distefano; Antonio Segura; Ana Blanco

doi:10.3109/09273948.2014.943349

Clinical Manifestations and Outcomes of Syphilis-associated Uveitis in Northern Spain

Alex Fonollosa, Lorea Martinez-Indart, Joseba Artaraz, Agustin Martinez-Berriotxoa, Koldo Agirrebengoa, Miriam Garcia, Leire Lopez-Soria, Manuel Sorribas, David Diaz-Valle, Ricardo Blanco, Javier Rueda-Gotor, Alfredo Adan, Victor Llorenç, Miguel Cordero-Coma, Laura Distefano, Antonio Segura, Ana Blanco

Research output: Contribution to journal › Article › Research › peer-review

24 Citations (Scopus)

Abstract

© 2016 Taylor & Francis Group, LLC. Purpose: To describe the clinical characteristics and to assess visual prognosis of patients with syphilis-associated uveitis in northern Spain.Methods: Retrospective review of clinical records in eight general uveitis referral centers.Results: Since the year 2000, 50 patients have been diagnosed: 31 men and 19 women; median age was 41 (19-76) years. A total of 34% were co-infected with HIV and 24% presented systemic manifestations of syphilis. Median initial visual acuity and vision at last visit in 93 affected eyes was 20/50 (20/20-20/2000) and 20/22 (20/20-20/2000), respectively (p <.0001). The most frequent manifestation was papillitis (33.3%). Fifty percent of eyes with macular edema on admission presented worsening of visual acuity at last visit, whereas frequency of worsening in eyes without edema was 7.1% (p = 0.009).Conclusions: In our series, patients with syphilitic uveitis were more usually middle-aged men and were frequently co-infected with HIV. Although most patients showed posterior segment involvement, visual prognosis was good.

Original language	English
Pages (from-to)	147-152
Journal	Ocular Immunology and Inflammation
Volume	24
Issue number	2
DOIs	https://doi.org/10.3109/09273948.2014.943349
Publication status	Published - 3 Mar 2016

Keywords

HIV
MSM
syphilis
Treponema pallidum
uveitis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/09273948.2014.943349

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Fonollosa, A., Martinez-Indart, L., Artaraz, J., Martinez-Berriotxoa, A., Agirrebengoa, K., Garcia, M., Lopez-Soria, L., Sorribas, M., Diaz-Valle, D., Blanco, R., Rueda-Gotor, J., Adan, A., Llorenç, V., Cordero-Coma, M., Distefano, L., Segura, A., & Blanco, A. (2016). Clinical Manifestations and Outcomes of Syphilis-associated Uveitis in Northern Spain. Ocular Immunology and Inflammation, 24(2), 147-152. https://doi.org/10.3109/09273948.2014.943349

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abstract = "{\textcopyright} 2016 Taylor & Francis Group, LLC. Purpose: To describe the clinical characteristics and to assess visual prognosis of patients with syphilis-associated uveitis in northern Spain.Methods: Retrospective review of clinical records in eight general uveitis referral centers.Results: Since the year 2000, 50 patients have been diagnosed: 31 men and 19 women; median age was 41 (19-76) years. A total of 34% were co-infected with HIV and 24% presented systemic manifestations of syphilis. Median initial visual acuity and vision at last visit in 93 affected eyes was 20/50 (20/20-20/2000) and 20/22 (20/20-20/2000), respectively (p <.0001). The most frequent manifestation was papillitis (33.3%). Fifty percent of eyes with macular edema on admission presented worsening of visual acuity at last visit, whereas frequency of worsening in eyes without edema was 7.1% (p = 0.009).Conclusions: In our series, patients with syphilitic uveitis were more usually middle-aged men and were frequently co-infected with HIV. Although most patients showed posterior segment involvement, visual prognosis was good.",

keywords = "HIV, MSM, syphilis, Treponema pallidum, uveitis",

author = "Alex Fonollosa and Lorea Martinez-Indart and Joseba Artaraz and Agustin Martinez-Berriotxoa and Koldo Agirrebengoa and Miriam Garcia and Leire Lopez-Soria and Manuel Sorribas and David Diaz-Valle and Ricardo Blanco and Javier Rueda-Gotor and Alfredo Adan and Victor Lloren{\c c} and Miguel Cordero-Coma and Laura Distefano and Antonio Segura and Ana Blanco",

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Fonollosa, A, Martinez-Indart, L, Artaraz, J, Martinez-Berriotxoa, A, Agirrebengoa, K, Garcia, M, Lopez-Soria, L, Sorribas, M, Diaz-Valle, D, Blanco, R, Rueda-Gotor, J, Adan, A, Llorenç, V, Cordero-Coma, M, Distefano, L, Segura, A & Blanco, A 2016, 'Clinical Manifestations and Outcomes of Syphilis-associated Uveitis in Northern Spain', Ocular Immunology and Inflammation, vol. 24, no. 2, pp. 147-152. https://doi.org/10.3109/09273948.2014.943349

TY - JOUR

T1 - Clinical Manifestations and Outcomes of Syphilis-associated Uveitis in Northern Spain

AU - Fonollosa, Alex

AU - Martinez-Indart, Lorea

AU - Artaraz, Joseba

AU - Martinez-Berriotxoa, Agustin

AU - Agirrebengoa, Koldo

AU - Garcia, Miriam

AU - Lopez-Soria, Leire

AU - Sorribas, Manuel

AU - Diaz-Valle, David

AU - Blanco, Ricardo

AU - Rueda-Gotor, Javier

AU - Adan, Alfredo

AU - Llorenç, Victor

AU - Cordero-Coma, Miguel

AU - Distefano, Laura

AU - Segura, Antonio

AU - Blanco, Ana

PY - 2016/3/3

Y1 - 2016/3/3

N2 - © 2016 Taylor & Francis Group, LLC. Purpose: To describe the clinical characteristics and to assess visual prognosis of patients with syphilis-associated uveitis in northern Spain.Methods: Retrospective review of clinical records in eight general uveitis referral centers.Results: Since the year 2000, 50 patients have been diagnosed: 31 men and 19 women; median age was 41 (19-76) years. A total of 34% were co-infected with HIV and 24% presented systemic manifestations of syphilis. Median initial visual acuity and vision at last visit in 93 affected eyes was 20/50 (20/20-20/2000) and 20/22 (20/20-20/2000), respectively (p <.0001). The most frequent manifestation was papillitis (33.3%). Fifty percent of eyes with macular edema on admission presented worsening of visual acuity at last visit, whereas frequency of worsening in eyes without edema was 7.1% (p = 0.009).Conclusions: In our series, patients with syphilitic uveitis were more usually middle-aged men and were frequently co-infected with HIV. Although most patients showed posterior segment involvement, visual prognosis was good.

AB - © 2016 Taylor & Francis Group, LLC. Purpose: To describe the clinical characteristics and to assess visual prognosis of patients with syphilis-associated uveitis in northern Spain.Methods: Retrospective review of clinical records in eight general uveitis referral centers.Results: Since the year 2000, 50 patients have been diagnosed: 31 men and 19 women; median age was 41 (19-76) years. A total of 34% were co-infected with HIV and 24% presented systemic manifestations of syphilis. Median initial visual acuity and vision at last visit in 93 affected eyes was 20/50 (20/20-20/2000) and 20/22 (20/20-20/2000), respectively (p <.0001). The most frequent manifestation was papillitis (33.3%). Fifty percent of eyes with macular edema on admission presented worsening of visual acuity at last visit, whereas frequency of worsening in eyes without edema was 7.1% (p = 0.009).Conclusions: In our series, patients with syphilitic uveitis were more usually middle-aged men and were frequently co-infected with HIV. Although most patients showed posterior segment involvement, visual prognosis was good.

KW - HIV

KW - MSM

KW - syphilis

KW - Treponema pallidum

KW - uveitis

U2 - 10.3109/09273948.2014.943349

DO - 10.3109/09273948.2014.943349

M3 - Article

VL - 24

SP - 147

EP - 152

IS - 2

ER -

Clinical Manifestations and Outcomes of Syphilis-associated Uveitis in Northern Spain

Abstract

Keywords

UN SDGs

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