TY - JOUR
T1 - Clinical features, diagnosis, and survival analysis of dogs with glioma
AU - José-López, Roberto
AU - Gutierrez-Quintana, Rodrigo
AU - de la Fuente, Cristian
AU - Manzanilla, Edgar G.
AU - Suñol, Anna
AU - Pi Castro, Dolors
AU - Añor, Sonia
AU - Sánchez-Masian, Daniel
AU - Fernández-Flores, Francisco
AU - Ricci, Emanuele
AU - Marioni-Henry, Katia
AU - Mascort, Joan
AU - Matiasek, Lara A.
AU - Matiasek, Kaspar
AU - Brennan, Paul M.
AU - Pumarola, Martí
N1 - © 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
PY - 2021/7/1
Y1 - 2021/7/1
N2 - BACKGROUND: Gliomas in dogs remain poorly understood.OBJECTIVES: To characterize the clinicopathologic findings, diagnostic imaging features and survival of a large sample of dogs with glioma using the Comparative Brain Tumor Consortium diagnostic classification.ANIMALS: Ninety-one dogs with histopathological diagnosis of glioma.METHODS: Multicentric retrospective case series. Signalment, clinicopathologic findings, diagnostic imaging characteristics, treatment, and outcome were used. Tumors were reclassified according to the new canine glioma diagnostic scheme.RESULTS: No associations were found between clinicopathologic findings or survival and tumor type or grade. However, definitive treatments provided significantly (P = .03) improved median survival time (84 days; 95% confidence interval [CI], 45-190) compared to palliative treatment (26 days; 95% CI, 11-54). On magnetic resonance imaging (MRI), oligodendrogliomas were associated with smooth margins and T1-weighted hypointensity compared to astrocytomas (odds ratio [OR], 42.5; 95% CI, 2.42-744.97; P = .04; OR, 45.5; 95% CI, 5.78-333.33; P < .001, respectively) and undefined gliomas (OR, 84; 95% CI, 3.43-999.99; P = .02; OR, 32.3; 95% CI, 2.51-500.00; P = .008, respectively) and were more commonly in contact with the ventricles than astrocytomas (OR, 7.47; 95% CI, 1.03-53.95; P = .049). Tumor spread to neighboring brain structures was associated with high-grade glioma (OR, 6.02; 95% CI, 1.06-34.48; P = .04).CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with gliomas have poor outcomes, but risk factors identified in survival analysis inform prognosis and the newly identified MRI characteristics could refine diagnosis of tumor type and grade.
AB - BACKGROUND: Gliomas in dogs remain poorly understood.OBJECTIVES: To characterize the clinicopathologic findings, diagnostic imaging features and survival of a large sample of dogs with glioma using the Comparative Brain Tumor Consortium diagnostic classification.ANIMALS: Ninety-one dogs with histopathological diagnosis of glioma.METHODS: Multicentric retrospective case series. Signalment, clinicopathologic findings, diagnostic imaging characteristics, treatment, and outcome were used. Tumors were reclassified according to the new canine glioma diagnostic scheme.RESULTS: No associations were found between clinicopathologic findings or survival and tumor type or grade. However, definitive treatments provided significantly (P = .03) improved median survival time (84 days; 95% confidence interval [CI], 45-190) compared to palliative treatment (26 days; 95% CI, 11-54). On magnetic resonance imaging (MRI), oligodendrogliomas were associated with smooth margins and T1-weighted hypointensity compared to astrocytomas (odds ratio [OR], 42.5; 95% CI, 2.42-744.97; P = .04; OR, 45.5; 95% CI, 5.78-333.33; P < .001, respectively) and undefined gliomas (OR, 84; 95% CI, 3.43-999.99; P = .02; OR, 32.3; 95% CI, 2.51-500.00; P = .008, respectively) and were more commonly in contact with the ventricles than astrocytomas (OR, 7.47; 95% CI, 1.03-53.95; P = .049). Tumor spread to neighboring brain structures was associated with high-grade glioma (OR, 6.02; 95% CI, 1.06-34.48; P = .04).CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with gliomas have poor outcomes, but risk factors identified in survival analysis inform prognosis and the newly identified MRI characteristics could refine diagnosis of tumor type and grade.
KW - astrocytoma
KW - dog
KW - magnetic resonance imaging
KW - oligodendroglioma
KW - prognosis
KW - tumor grade
KW - undefined glioma
UR - http://www.scopus.com/inward/record.url?scp=85107753175&partnerID=8YFLogxK
U2 - 10.1111/jvim.16199
DO - 10.1111/jvim.16199
M3 - Article
C2 - 34117807
AN - SCOPUS:85107753175
VL - 35
SP - 1902
EP - 1917
IS - 4
ER -