Clinical evaluation of pimecrolimus eye drops for treatment of canine keratoconjunctivitis sicca: A comparison with cyclosporine A

Ron Ofri; George N. Lambrou; Ingrid Allgoewer; Uwe Graenitz; Teresa M. Pena; Bernhard M. Spiess; Elisabeth Latour

doi:https://doi.org/10.1016/j.tvjl.2007.08.034

Clinical evaluation of pimecrolimus eye drops for treatment of canine keratoconjunctivitis sicca: A comparison with cyclosporine A

Ron Ofri, George N. Lambrou, Ingrid Allgoewer, Uwe Graenitz, Teresa M. Pena, Bernhard M. Spiess, Elisabeth Latour

Department of Animal Medicine and Surgery

Research output: Contribution to journal › Article › Research › peer-review

24 Citations (Scopus)

Abstract

The aim of this study was to evaluate the efficacy of pimecrolimus oil-based eye drops in alleviating the clinical signs of keratoconjunctivitis sicca (KCS) in dogs and to compare the efficacy with that of cyclosporine A (CsA) ointment. An open-label, multicenter study enrolling 44 dogs previously untreated with CsA was conducted. Dogs were randomly assigned to a treatment group and medicated twice daily for 8 weeks. After that time the mean increase (±SEM) in the Schirmer tear test was 9.2 ± 1.6 mm/min in the pimecrolimus group and 5.8 ± 1.1 mm/min in the CsA group (P = 0.085). The improvement in clinical signs of inflammation in eyes treated with pimecrolimus was significantly greater than in eyes treated with CsA (P = 0.02). The results show that 1% pimecrolimus oily eye drops are as safe as and more effective than CsA ointment in controlling KCS in dogs. © 2007 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	70-77
Journal	Veterinary Journal
Volume	179
DOIs	https://doi.org/10.1016/j.tvjl.2007.08.034
Publication status	Published - 1 Jan 2009

Keywords

Cyclosporine A
Dog
Dry eye
Keratoconjunctivitis sicca
Pimecrolimus

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title = "Clinical evaluation of pimecrolimus eye drops for treatment of canine keratoconjunctivitis sicca: A comparison with cyclosporine A",

abstract = "The aim of this study was to evaluate the efficacy of pimecrolimus oil-based eye drops in alleviating the clinical signs of keratoconjunctivitis sicca (KCS) in dogs and to compare the efficacy with that of cyclosporine A (CsA) ointment. An open-label, multicenter study enrolling 44 dogs previously untreated with CsA was conducted. Dogs were randomly assigned to a treatment group and medicated twice daily for 8 weeks. After that time the mean increase (±SEM) in the Schirmer tear test was 9.2 ± 1.6 mm/min in the pimecrolimus group and 5.8 ± 1.1 mm/min in the CsA group (P = 0.085). The improvement in clinical signs of inflammation in eyes treated with pimecrolimus was significantly greater than in eyes treated with CsA (P = 0.02). The results show that 1% pimecrolimus oily eye drops are as safe as and more effective than CsA ointment in controlling KCS in dogs. {\textcopyright} 2007 Elsevier Ltd. All rights reserved.",

keywords = "Cyclosporine A, Dog, Dry eye, Keratoconjunctivitis sicca, Pimecrolimus",

author = "Ron Ofri and Lambrou, {George N.} and Ingrid Allgoewer and Uwe Graenitz and Pena, {Teresa M.} and Spiess, {Bernhard M.} and Elisabeth Latour",

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doi = "https://doi.org/10.1016/j.tvjl.2007.08.034",

language = "English",

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AU - Ofri, Ron

AU - Lambrou, George N.

AU - Allgoewer, Ingrid

AU - Graenitz, Uwe

AU - Pena, Teresa M.

AU - Spiess, Bernhard M.

AU - Latour, Elisabeth

PY - 2009/1/1

Y1 - 2009/1/1

N2 - The aim of this study was to evaluate the efficacy of pimecrolimus oil-based eye drops in alleviating the clinical signs of keratoconjunctivitis sicca (KCS) in dogs and to compare the efficacy with that of cyclosporine A (CsA) ointment. An open-label, multicenter study enrolling 44 dogs previously untreated with CsA was conducted. Dogs were randomly assigned to a treatment group and medicated twice daily for 8 weeks. After that time the mean increase (±SEM) in the Schirmer tear test was 9.2 ± 1.6 mm/min in the pimecrolimus group and 5.8 ± 1.1 mm/min in the CsA group (P = 0.085). The improvement in clinical signs of inflammation in eyes treated with pimecrolimus was significantly greater than in eyes treated with CsA (P = 0.02). The results show that 1% pimecrolimus oily eye drops are as safe as and more effective than CsA ointment in controlling KCS in dogs. © 2007 Elsevier Ltd. All rights reserved.

AB - The aim of this study was to evaluate the efficacy of pimecrolimus oil-based eye drops in alleviating the clinical signs of keratoconjunctivitis sicca (KCS) in dogs and to compare the efficacy with that of cyclosporine A (CsA) ointment. An open-label, multicenter study enrolling 44 dogs previously untreated with CsA was conducted. Dogs were randomly assigned to a treatment group and medicated twice daily for 8 weeks. After that time the mean increase (±SEM) in the Schirmer tear test was 9.2 ± 1.6 mm/min in the pimecrolimus group and 5.8 ± 1.1 mm/min in the CsA group (P = 0.085). The improvement in clinical signs of inflammation in eyes treated with pimecrolimus was significantly greater than in eyes treated with CsA (P = 0.02). The results show that 1% pimecrolimus oily eye drops are as safe as and more effective than CsA ointment in controlling KCS in dogs. © 2007 Elsevier Ltd. All rights reserved.

KW - Cyclosporine A

KW - Dog

KW - Dry eye

KW - Keratoconjunctivitis sicca

KW - Pimecrolimus

U2 - https://doi.org/10.1016/j.tvjl.2007.08.034

DO - https://doi.org/10.1016/j.tvjl.2007.08.034

M3 - Article

VL - 179

SP - 70

EP - 77

ER -

Clinical evaluation of pimecrolimus eye drops for treatment of canine keratoconjunctivitis sicca: A comparison with cyclosporine A

Abstract

Keywords

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